| Texto completo | |
| Autor(es): |
Medeiros, Jilvando M.
;
Oliveira, Isadora S.
;
Ferreira, Isabela G.
;
Alexandre-Silva, Gabriel Melo
;
Cerni, Felipe A.
;
Zottich, Umberto
;
Pucca, Manuela B.
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | REPORTS; v. 3, n. 2, p. 12-pg., 2020-06-01. |
| Resumo | |
Snakebite envenomations are classified as Category A Neglected Tropical Diseases by the World Health Organization. In Brazil, 405 snake species are distributed among 11 families, with the genera Bothrops and Crotalus being the most studied and main responsible for severe and lethal envenomations. In the country, Crotalus genus (i.e., rattlesnakes) is represented by Crotalus durissus species, showing seven different subspecies distributed along the country, including Crotalus durissus ruruima, which inhabits Roraima, the Brazilian nothermost state from Amazon forest. Here, we report a fatal case of a severe envenomation following a rattlesnake bite. The patient presented classic crotalic neurological signs and symptoms such as ptosis, drooling of saliva, sluggishness, macroscopic hematuria, and oliguria, which evolved to acute kidney failure (AKF) and hemodynamic instability. Although the patient was treated with the specific antivenom therapy, the severe envenomation resulted in three cardiac arrests and death of the victim in less than 38 h. This study discusses the causes of the patient death, the features of rattlesnake venom-induced AKF, and shows evidences that the Brazilian crotalic antivenom should be improved to treat rattlesnake envenomations caused by C. d. ruruima venom in Roraima state. (AU) | |
| Processo FAPESP: | 17/03580-9 - Avaliação bioquímica, estrutural e funcional de uma fosfodiesterase da peçonha de Crotalus durissus collilineatus |
| Beneficiário: | Isadora Sousa de Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 17/14035-1 - Melhoramento de fragmentos de anticorpos humanos (scFVs) específicos para peçonhas animais |
| Beneficiário: | Felipe Augusto Cerni |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |