| Texto completo | |
| Autor(es): Mostrar menos - |
Costa, Frederico R. C.
;
Leite, Jefferson A.
;
Rassi, Diane M.
;
da Silva, Josiane F.
;
Elias-Oliveira, Jefferson
;
Guimaraes, Jhefferson B.
;
Foss-Freitas, Maria C.
;
Camara, Niels O. S.
;
Pontillo, Alessandra
;
Tostes, Rita C.
;
Silva, Joao S.
;
Carlos, Daniela
Número total de Autores: 12
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CELL REPORTS; v. 35, n. 8, p. 15-pg., 2021-05-25. |
| Resumo | |
Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of pancreatic beta cells, We show here that the protein NOD-like receptor family pyrin domain containing 1 (NLRP1) has a key role in the pathogenesis of mouse and human T1D. More specifically, downregulation of NLRP1 expression occurs during T helper 17 (Th17) differentiation, alongside greater expression of several molecules related to Th17 cell differentiation in a signal transducers and activators of transcription 3 (STAT3)-dependent pathway. These changes lead to a consequent increase in interleukin 17 (IL-17) production within the pancreas and higher incidence of diabetes in streptozotocin (STZ)-injected mice. Finally, in patients with T1D and a SNP (rs12150220) in NLRP1, there is a robust decrease in IL-17 levels in serum and in memory Th17 cells from peripheral blood mononuclear cells. Our results demonstrate that NLRP1 acts as a negative regulator of the Th17 cell polarization program, making it an interesting target for intervention during the early stages of T1D. (AU) | |
| Processo FAPESP: | 13/08216-2 - CPDI - Centro de Pesquisa em Doenças Inflamatórias |
| Beneficiário: | Fernando de Queiroz Cunha |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 12/10395-0 - Papel dos receptores NLRs nos mecanismos de imunoregulação do diabetes do tipo 1 e 2: identificação de novos alvos terapêuticos |
| Beneficiário: | Daniela Carlos Sartori |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 18/14815-0 - Estudo do perfil do microbioma intestinal e do potencial terapêutico de estratégias de intervenção na imunopatogenia do Diabetes tipo 1 e 2 |
| Beneficiário: | Daniela Carlos Sartori |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2 |