Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer

Autor(es):Mostrar menos -

Lopez, R. V. M. ^[1] ; Zago, M. A. ^[2] ; Eluf-Neto, J. ^[3] ; Curado, M. P. ^{[4, 5]} ; Daudt, A. W. ^[6] ; da Silva-Junior, W. A. ^[2] ; Zanette, D. L. ^[2] ; Levi, J. E. ^[7] ; de Carvalho, M. B. ^[8] ; Kowalski, L. P. ^[9] ; Abrahao, M. ^[10] ; de Gois-Filho, J. F. ^[11] ; Boffetta, P. ^{[12, 13]} ; Wuensch-Filho, V. ^[1]

Afiliação do(s) autor(es):Mostrar menos -

^[1] Univ Sao Paulo, Dept Epidemiol, Fac Saude Publ, BR-01246904 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Genet Mol Lab, Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Dept Prevent Med, Fac Med, BR-01246904 Sao Paulo - Brazil

^[4] Hosp Araujo Jorge & Registro Canc Base Populac Go, Goiania, Go - Brazil

^[5] World Hlth Org, Int Agcy Res Canc, Lyon - France

^[6] Hosp Clin Porto Alegre, Dept Oncol, Porto Alegre, RS - Brazil

^[7] Univ Sao Paulo, Virol Lab, Inst Trop Med, BR-01246904 Sao Paulo - Brazil

^[8] Hosp Heliopolis, Dept Cirurgia Cabeca & Pescoco, Sao Paulo - Brazil

^[9] Hosp Canc AC Camargo, Dept Cirurgia Cabeca & Pescoco, Sao Paulo - Brazil

^[10] Univ Fed Sao Paulo, Dept Otorrinolaringol & Disturbios Comunicacao, Sao Paulo - Brazil

^[11] Inst Canc Arnaldo Vieira de Carvalho, Dept Cirurgia Cabeca & Pescoco, Sao Paulo - Brazil

^[12] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY - USA

^[13] Int Prevent Res Inst, Lyon - France

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 44, n. 10, p. 1006-1012, OCT 2011.
• Citações Web of Science: 20

Resumo

The association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) of disease-specific survival according to anatomical sites of the head and neck. Mean age was 56 years and most patients were males (87.6%). Subjects with 5 or more years of schooling had better survival in larynx cancer. Smoking had no effect on HNSCC survival, but alcohol consumption had a statistically significant effect on larynx cancer. IL-2 gene +114 G/T (HR = 0.52; 95% CI = 0.15-1.81) and T/T (HR = 0.22; 95% CI = 0.02-3.19) genotypes were associated with better survival in hypopharynx cancer. IL-2 + 114 G/T was a predictor of poor survival in oral cavity/oropharynx cancer and larynx cancer (HR = 1.32; 95% CI = 0.61-2.85). IL-2 -384 G/T was associated with better survival in oral cavity/oropharynx cancer (HR = 0.80; 95% CI = 0.45-1.42) and hypopharynx cancer (HR = 0.68; 95% CI = 0.21-2.20), but an inverse relationship was observed for larynx cancer. IL-6 -174 G/C was associated with better survival in hypopharynx cancer (HR = 0.68; 95% CI = 0.26-1.78) and larynx cancer (HR = 0.93; 95% CI = 0.42-2.07), and C/C reduced mortality in larynx cancer. In general, our results are similar to previous reports on the value of education, smoking, alcohol consumption, and IL-2 and IL-6 genetic polymorphisms for the prognosis of HNSCC, but the risks due to these variables are small and estimates imprecise. (AU)

• Processo FAPESP: 01/01768-2 - Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe
• Beneficiário: José Eluf Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/50832-6 - Polimorfismos geneticos e prognostico de tumores de cabeca e pescoco.
• Beneficiário: Victor Wünsch Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular