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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer

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Author(s):
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Lopez, R. V. M. [1] ; Zago, M. A. [2] ; Eluf-Neto, J. [3] ; Curado, M. P. [4, 5] ; Daudt, A. W. [6] ; da Silva-Junior, W. A. [2] ; Zanette, D. L. [2] ; Levi, J. E. [7] ; de Carvalho, M. B. [8] ; Kowalski, L. P. [9] ; Abrahao, M. [10] ; de Gois-Filho, J. F. [11] ; Boffetta, P. [12, 13] ; Wuensch-Filho, V. [1]
Total Authors: 14
Affiliation:
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[1] Univ Sao Paulo, Dept Epidemiol, Fac Saude Publ, BR-01246904 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Genet Mol Lab, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Dept Prevent Med, Fac Med, BR-01246904 Sao Paulo - Brazil
[4] Hosp Araujo Jorge & Registro Canc Base Populac Go, Goiania, Go - Brazil
[5] World Hlth Org, Int Agcy Res Canc, Lyon - France
[6] Hosp Clin Porto Alegre, Dept Oncol, Porto Alegre, RS - Brazil
[7] Univ Sao Paulo, Virol Lab, Inst Trop Med, BR-01246904 Sao Paulo - Brazil
[8] Hosp Heliopolis, Dept Cirurgia Cabeca & Pescoco, Sao Paulo - Brazil
[9] Hosp Canc AC Camargo, Dept Cirurgia Cabeca & Pescoco, Sao Paulo - Brazil
[10] Univ Fed Sao Paulo, Dept Otorrinolaringol & Disturbios Comunicacao, Sao Paulo - Brazil
[11] Inst Canc Arnaldo Vieira de Carvalho, Dept Cirurgia Cabeca & Pescoco, Sao Paulo - Brazil
[12] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY - USA
[13] Int Prevent Res Inst, Lyon - France
Total Affiliations: 13
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 44, n. 10, p. 1006-1012, OCT 2011.
Web of Science Citations: 20
Abstract

The association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) of disease-specific survival according to anatomical sites of the head and neck. Mean age was 56 years and most patients were males (87.6%). Subjects with 5 or more years of schooling had better survival in larynx cancer. Smoking had no effect on HNSCC survival, but alcohol consumption had a statistically significant effect on larynx cancer. IL-2 gene +114 G/T (HR = 0.52; 95% CI = 0.15-1.81) and T/T (HR = 0.22; 95% CI = 0.02-3.19) genotypes were associated with better survival in hypopharynx cancer. IL-2 + 114 G/T was a predictor of poor survival in oral cavity/oropharynx cancer and larynx cancer (HR = 1.32; 95% CI = 0.61-2.85). IL-2 -384 G/T was associated with better survival in oral cavity/oropharynx cancer (HR = 0.80; 95% CI = 0.45-1.42) and hypopharynx cancer (HR = 0.68; 95% CI = 0.21-2.20), but an inverse relationship was observed for larynx cancer. IL-6 -174 G/C was associated with better survival in hypopharynx cancer (HR = 0.68; 95% CI = 0.26-1.78) and larynx cancer (HR = 0.93; 95% CI = 0.42-2.07), and C/C reduced mortality in larynx cancer. In general, our results are similar to previous reports on the value of education, smoking, alcohol consumption, and IL-2 and IL-6 genetic polymorphisms for the prognosis of HNSCC, but the risks due to these variables are small and estimates imprecise. (AU)