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Detection and characterization of molecular alterations in tissue samples and body fluids from patients with head and neck tumors

Grant number: 17/22658-9
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2018
Effective date (End): March 25, 2020
Field of knowledge:Health Sciences - Medicine
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Ana Carolina de Carvalho Peters
Grantee:Lais Machado de Jesus
Home Institution: Hospital do Câncer de Barretos. Fundação Pio XII (FP). Barretos , SP, Brazil
Associated scholarship(s):19/12785-9 - Detection and characterization of molecular alterations in tissue and body fluids from patients with head and neck tumors, BE.EP.MS

Abstract

Head and neck squamous cell carcinomas (HNSCC) have as main risk factor the consumption of alcohol and tobacco, besides also being associated with infection by the human papilloma virus (HPV), especially in oropharyngeal tumors. They are commonly related to high rates of incidence, morbidity and mortality, presenting a great complexity in the management of the patients because of their etiological, molecular and clinical heterogeneity.Therefore, the identification of molecular markers that enable a better classification of these patients in according to their clinical evolution and that can be evaluated in body fluids, reducing the necessity of invasive diagnostic biopsies during the follow-up may improve the choice of clinical conduct regarding patients management. For this reason, the objective of this study is to characterize genetic and epigenetic alterations in specific genes important for carcinogenesis, tumor samples and body fluids of patients with HCSCC treated at the Head and Neck Surgery Department of the Barretos Cancer Hospital. It is expected with the results found, it will be possible to identify changes in these genes in the tumors and to evaluate them as markers of response to treatment and monitoring during the follow-up of patients, searching at a better choice of conduct in the decision of the treatment and the form of follow-up, allowing improvement in the quality of life and survival rates. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE JESUS, LAIS MACHADO; DOS REIS, MARIANA BISARRO; CARVALHO, RAIANY SANTOS; SCAPULATEMPO NETO, CRISTOVAM; DE ALMEIDA, GISELE CARAVINA; LAUS, ANA CAROLINA; MARCZYNSKI, GABRIELLA TAQUES; LEAL, LETICIA FERRO; MELENDEZ, MATIAS ELISEO; DE MARCHI, PEDRO; MANUEL REIS, RUI; CARVALHO, ANDRE LOPES; DE CARVALHO, ANA CAROLINA. Feasibility of methylatedctDNAdetection in plasma samples of oropharyngeal squamous cell carcinoma patients. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, JUL 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.