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Impact of Sleeve Gastrectomy on Body Weight and Food Intake Regulation in Diet-Induced Obese Mice

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Autor(es):
Balbo, Sandra Lucinei ; Soares, Gabriela Moreira ; Morari, Joseane ; Felisberto Jr, Antonio Machado ; Vettorazzi, Jean Franciesco ; Bronczek, Gabriela Alves ; Bonfleur, Maria Lucia ; Carneiro, Everardo Magalhaes ; Boschero, Antonio Carlos ; Velloso, Licio Augusto
Número total de Autores: 10
Tipo de documento: Artigo Científico
Fonte: CURRENT ISSUES IN MOLECULAR BIOLOGY; v. 46, n. 11, p. 8-pg., 2024-11-01.
Resumo

The epidemic of obesity has increased worldwide and is associated with comorbidities such as diabetes and cardiovascular disease. In this context, strategies that modulate body weight and improve glycemic metabolism have increased, and bariatric surgeries such as Sleeve Gastrectomy (SG) have been highlighted in obesity treatment. However, the mechanism by which SG reduces body weight and improves glycemic control remains unknown. Thus, in this study, we aimed to evaluate food intake and the expression of hypothalamic genes involved with the regulation of this process in diet-induced obese mice submitted to SG. For this, we used C57BL/6 mice submitted to a 10-week high-fat diet protocol and submitted to SG. Food intake, fed and fasted glycemia, as well as hypothalamic anorexigenic and orexigenic gene expression were evaluated 4 weeks after the surgical procedure. First, we observed that SG reduces body weight (44.19 +/- 0.47 HFD, 43.51 +/- 0.71 HFD-SHAM, and 38.22 +/- 1.31 HFD-SG), fasting glycemia (115.0 +/- 4.60 HFD, 122.4 +/- 3.48 HFD-SHAM, and 93.43 +/- 4.67 HFD-SG), insulinemia (1.77 +/- 0.15 HFD, 1.92 +/- 0.27 HFD-SHAM, and 0.93 +/- 0.05 HFD-SG), and leptinemia (5.86 +/- 1.38 HFD, 6.44 +/- 1.51 HFD-SHAM, and 1.43 +/- 0.35 HFD-SG) in obese mice. Additionally, SG reduces food (5.15 +/- 0.18 HFD, 5.49 +/- 0.32, HFD-SHAM, and 3.28 +/- 0.26 HFD-SG) and total (16.88 +/- 0.88 HFD, 17.05 +/- 0.42, HFD-SHAM, and 14.30 +/- 0.73 HFD-SG) calorie intake without alterations in anorexigenic and orexigenic gene expression. In conclusion, these data indicate that SG improves obesity-associated alterations at least in part by a reduction in food intake. This effect is not associated with the canonical food intake pathway in the hypothalamus, indicating the involvement of non-canonical pathways in this process. (AU)

Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
Beneficiário:Licio Augusto Velloso
Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 15/12611-0 - Mecanismos moleculares envolvidos na disfunção e morte de células beta pancreáticas no Diabetes mellitus: estratégias para a inibição desses processos e para a recuperação da massa insular
Beneficiário:Antonio Carlos Boschiero
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 21/04664-7 - Mecanismos moleculares envolvidos na disfunção e morte de células beta-pancreáticas no Diabetes Mellitus: estratégias para a inibição desses processos e para a recuperação da massa insular
Beneficiário:Antonio Carlos Boschiero
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 19/00728-0 - Papel da inter-relação intestino-pâncreas na manutenção da homeostase glicêmica de camundongos obesos submetidos à gastrectomia vertical: uma abordagem molecular e funcional
Beneficiário:Gabriela Moreira Soares
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado