A link between sleep loss, glucose metabolism and adipokines

Autor(es)

Padilha, H. G. ; Crispim, C. A. ^[1] ; Zimberg, I. Z. ; De-Souza, D. A. ^[1] ; Waterhouse, J. ^[2] ; Tufik, S. ; de-Mello, M. T. ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Uberlandia, Fac Med, BR-38400 Uberlandia, MG - Brazil

^[2] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool L3 5UX, Merseyside - England

^[3] Univ Fed Sao Paulo, CEPE, Dept Psicobiol, BR-04020060 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Brazilian Journal of Medical and Biological Research; v. 44, n. 10, p. 992-999, OCT 2011.
• Citações Web of Science: 11

Resumo

The present review evaluates the role of sleep and its alteration in triggering problems of glucose metabolism and the possible involvement of adipokines in this process. A reduction in the amount of time spent sleeping has become an endemic condition in modern society, and a search of the current literature has found important associations between sleep loss and alterations of nutritional and metabolic contexts. Studies suggest that sleep loss is associated with problems in glucose metabolism and a higher risk for the development of insulin resistance and type 2 diabetes mellitus. The mechanism involved may be associated with the decreased efficacy of regulation of the hypothalamus-pituitary-adrenal axis by negative feedback mechanisms in sleep-deprivation conditions. In addition, changes in the circadian pattern of growth hormone (GH) secretion might also contribute to the alterations in glucose regulation observed during sleep loss. On the other hand, sleep deprivation stress affects adipokines - increasing tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) and decreasing leptin and adiponectin -, thus establishing a possible association between sleep-debt, adipokines and glucose metabolism. Thus, a modified release of adipokines resulting from sleep deprivation could lead to a chronic sub-inflammatory state that could play a central role in the development of insulin resistance and type 2 diabetes mellitus. Further studies are necessary to investigate the role of sleep loss in adipokine release and its relationship with glucose metabolism. (AU)

• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs