Pharmacological dose of alpha-tocopherol induces cardiotoxicity in Wistar rats determined by echocardiography and histology

Autor(es):Mostrar menos -

Nascimento, Maria Carolina M. O. ^[1] ; Matsubara, Beatriz B. ^[1] ; Matsubara, Luiz S. ^[1] ; Correa, Camila R. ^[1] ; Pereira, Elenize J. ^[1] ; Moreira, Priscila L. ^[1] ; Carvalho, Flavio A. ^[1] ; Burini, Caio H. ^[2] ; Padovani, Carlos R. ^[3] ; Yeum, Kyung-Jin ^[4] ; Ferreira, Ana Lucia A. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, UNESP, Botucatu Sch Med, Dept Internal Med, Botucatu, SP - Brazil

^[2] Sao Paulo State Univ, UNESP, Sch Vet Med, Dept Vet Pathol, Botucatu, SP - Brazil

^[3] Sao Paulo State Univ, UNESP, Inst Biociencias, Dept Biostat, Botucatu, SP - Brazil

^[4] Tufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 - USA

• Tipo de documento: Artigo Científico
• Fonte: HUMAN & EXPERIMENTAL TOXICOLOGY; v. 30, n. 10, p. 1540-1548, OCT 2011.
• Citações Web of Science: 4

Resumo

The effect of pharmacological dose of cc-tocopherol on heart health was determined in Wistar rats. Animals were randomly assigned to either C (control, n = II) or E (cc-tocopherol, n = II) group. Animals received corn oil (C) or alpha-tocopherol dissolved in corn oil (250 mg alpha-tocopherol/{[}kg body wt/day]) (E) by gavage for a 7-week period. Rats underwent echocardiogram and were analyzed for cardiomyocyte histology and cardiac cc-tocopherol absorption at the end of the study period. As compared to the C group, alpha-tocopherol-supplemented group showed significantly (p < 0.05) lower body weight (E, 412.8 g vs C, 480.3 g) and total cardiac weight (E, 0.94 g vs C, 1.08 g); cardiomyocyte histological impairment; smaller left ventricle (LV) (LV end-diastolic diameter (E, 7.22 mm vs C, 7.37 mm), lower LV systolic {[}left ventricle fractional shortening (E, 47.6% vs C, 53.6%) and ejection fraction ratio (E, 85.4 vs C, 89.9)] and diastolic {[}early peak velocities of diastolic transmitral flow (E, 64.6 cm/sec vs C, 75.1 cm/sec)] function. The alpha-tocopherol uptake in target tissue was confirmed by determination of alpha-tocopherol concentration medians in cardiac tissue (E, 109.91 nmol/kg vs C, 52.09 nmol/kg). The current study indicates that pharmacological dose of alpha-tocopherol supplementation can induce cardiotoxicity in healthy rats. (AU)

• Processo FAPESP: 05/52571-5 - Efeito do alfa-tocoferol e do licopeno sobre a cardiotoxicidade induzida pela adriamicina em ratos: estudo funcional e histológico
• Beneficiário: Flávio Augusto de Carvalho
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica