Minimal Functionalization of Ruthenium Compounds with Enhanced Photoreactivity against Hard-to-Treat Cancer Cells and Resistant Bacteria

Autor(es)

Sousa Oliveira, Geangela de Fatima ; Gouveia, Florencio Sousa ; Andrade, Alexandre Lopes ; de Vasconcelos, Mayron Alves ; Teixeira, Edson Holanda ; Palmeira-Mello, Marcos V. ; Batista, Alzir A. ; Lopes, Luiz Gonzaga de Franca ; de Carvalho, Idalina Maria Moreira ; Sousa, Eduardo Henrique Silva

• Tipo de documento: Artigo Científico
• Fonte: Inorganic Chemistry; v. 63, n. 31, p. 18-pg., 2024-07-23.

Resumo

Metallocompounds have emerged as promising new anticancer agents, which can also exhibit properties to be used in photodynamic therapy. Here, we prepared two ruthenium-based compounds with a 2,2 '-bipyridine ligand conjugated to an anthracenyl moiety. These compounds coded GRBA and GRPA contain 2,2 '-bipyridine or 1,10-phenathroline as auxiliary ligands, respectively, which provide quite a distinct behavior. Notably, compound GRPA exhibited remarkably high photoproduction of singlet oxygen even in water (phi(Delta) = 0.96), almost twice that of GRBA (phi(Delta) = 0.52). On the other hand, this latter produced twice more superoxide and hydroxyl radical species than GRPA, which may be due to the modulation of their excited state. Interestingly, GRPA exhibited a modest binding to DNA (K-b = 4.51 x 10(4)), while GRBA did not show a measurable interaction only noticed by circular dichroism measurements. Studies with bacteria showed a great antimicrobial effect, including a synergistic effect in combination with commercial antibiotics. Besides that, GRBA showed very low or no cytotoxicity against four mammalian cells, including a hard-to-treat MDA-MB-231, triple-negative human breast cancer. Potent activities were measured for GRBA upon blue light irradiation, where IC50 of 43 and 13 nmol L-1 were seen against hard-to-treat triple-negative human breast cancer (MDA-MB-231) and ovarian cancer cells (A2780), respectively. These promising results are an interesting case of a simple modification with expressive enhancement of biological activity that deserves further biological studies. (AU)

• Processo FAPESP: 21/01787-0 - Estudo in vitro e in vivo de complexos fosfínicos de Ru(II) com atividades anticancerígenas
• Beneficiário: Marcos Vinícius Palmeira de Mello
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado