| Texto completo | |
| Autor(es): |
Sousa Oliveira, Geangela de Fatima
;
Gouveia, Florencio Sousa
;
Andrade, Alexandre Lopes
;
de Vasconcelos, Mayron Alves
;
Teixeira, Edson Holanda
;
Palmeira-Mello, Marcos V.
;
Batista, Alzir A.
;
Lopes, Luiz Gonzaga de Franca
;
de Carvalho, Idalina Maria Moreira
;
Sousa, Eduardo Henrique Silva
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Inorganic Chemistry; v. 63, n. 31, p. 18-pg., 2024-07-23. |
| Resumo | |
Metallocompounds have emerged as promising new anticancer agents, which can also exhibit properties to be used in photodynamic therapy. Here, we prepared two ruthenium-based compounds with a 2,2 '-bipyridine ligand conjugated to an anthracenyl moiety. These compounds coded GRBA and GRPA contain 2,2 '-bipyridine or 1,10-phenathroline as auxiliary ligands, respectively, which provide quite a distinct behavior. Notably, compound GRPA exhibited remarkably high photoproduction of singlet oxygen even in water (phi(Delta) = 0.96), almost twice that of GRBA (phi(Delta) = 0.52). On the other hand, this latter produced twice more superoxide and hydroxyl radical species than GRPA, which may be due to the modulation of their excited state. Interestingly, GRPA exhibited a modest binding to DNA (K-b = 4.51 x 10(4)), while GRBA did not show a measurable interaction only noticed by circular dichroism measurements. Studies with bacteria showed a great antimicrobial effect, including a synergistic effect in combination with commercial antibiotics. Besides that, GRBA showed very low or no cytotoxicity against four mammalian cells, including a hard-to-treat MDA-MB-231, triple-negative human breast cancer. Potent activities were measured for GRBA upon blue light irradiation, where IC50 of 43 and 13 nmol L-1 were seen against hard-to-treat triple-negative human breast cancer (MDA-MB-231) and ovarian cancer cells (A2780), respectively. These promising results are an interesting case of a simple modification with expressive enhancement of biological activity that deserves further biological studies. (AU) | |
| Processo FAPESP: | 21/01787-0 - Estudo in vitro e in vivo de complexos fosfínicos de Ru(II) com atividades anticancerígenas |
| Beneficiário: | Marcos Vinícius Palmeira de Mello |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |