Tissue-specific roles of mitochondrial unfolded protein response during obesity

Autor(es)

Carneiro, Fernanda S. ; Katashima, Carlos K. ; Dodge, Joshua D. ; Cintra, Dennys E. ; Pauli, Jose Rodrigo ; Da Silva, Adelino S. R. ; Ropelle, Eduardo R.

• Tipo de documento: Artigo Científico
• Fonte: Obesity Reviews; v. 25, n. 9, p. 15-pg., 2024-06-16.

Resumo

Obesity is a worldwide multifactorial disease caused by an imbalance in energy metabolism, increasing adiposity, weight gain, and promoting related diseases such as diabetes, cardiovascular diseases, neurodegeneration, and cancer. Recent findings have reported that metabolic stress related to obesity induces a mitochondrial stress response called mitochondrial unfolded protein response (UPRmt), a quality control pathway that occurs in a nuclear DNA-mitochondria crosstalk, causing transduction of chaperones and proteases under stress conditions. The duality of UPRmt signaling, with both beneficial and detrimental effects, acts in different contexts depending on the tissue, cell type, and physiological states, affecting the mitochondrial function and efficiency and the metabolism homeostasis during obesity, which remains not fully clarified. Therefore, this review discusses the most recent findings regarding UPRmt signaling during obesity, bringing an overview of UPRmt across different metabolic tissues. (AU)

• Processo FAPESP: 22/02350-8 - Efeito do jejum intermitente sobre a UPRmt no hipotálamo de camundongos obesos
• Beneficiário: Fernanda Silva Carneiro
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 21/04292-2 - Implicações da interleucina-6 sobre a UPRmt no hipotálamo de camundongos obesos
• Beneficiário: Carlos Kiyoshi Katashima
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 19/21709-4 - Implicações do desequilíbrio mitonuclear e da UPRmt em neurônios hipotalâmicos na gênese da Obesidade
• Beneficiário: Eduardo Rochete Ropelle
• Modalidade de apoio: Auxílio à Pesquisa - Temático