Imported Cutaneous Leishmaniasis from Peru Caused by Leishmania (Viannia) guyanensis in a Brazilian Patient: Case Report and In Vitro Drug Susceptibility Analysis

Autor(es)

Coser, Elizabeth M. ; Aoki, Juliana I. ; Saborito, Cristiele ; de la Roca, Stephane ; Brufatto, Joao Paulo T. ; Angerami, Rodrigo ; Stelini, Rafael F. ; Velho, Paulo Eduardo N. F. ; Coelho, Adriano C.

• Tipo de documento: Artigo Científico
• Fonte: TROPICAL MEDICINE AND INFECTIOUS DISEASE; v. 9, n. 11, p. 7-pg., 2024-11-01.

Resumo

In South America, cutaneous leishmaniasis is caused by several species of the parasite of the genus Leishmania. Here, we describe an imported case of cutaneous leishmaniasis acquired in Peru by a Brazilian patient during her travel to Iquitos. Infection by Leishmania parasites was confirmed by histopathologic examination, and the patient was treated with pentavalent antimony (Pentostam), without clinical response. Molecular typing was performed by sequencing the ribosomal DNA internal transcribed spacer and heat-shock protein 70 gene, which identified the parasites as Leishmania guyanensis. The clinical isolate was similarly susceptible to amphotericin B, pentamidine, and miltefosine as the reference strain, while for pentavalent antimony, this clinical isolate was more susceptible than the reference strain, even though its susceptibility in vitro was still considered low. The patient was then treated with liposomal amphotericin B, with clinical improvement of the lesions. (AU)

• Processo FAPESP: 22/06176-2 - Caraterização de um isolado clínico de Leishmania amazonensis multirresistente aos fármacos utilizados no tratamento da leishmaniose
• Beneficiário: Stephane Soares Gomes Senhorinha
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 19/22175-3 - Identificação e validação funcional de genes associados à suscetibilidade e resistência à paromomicina em Leishmania spp
• Beneficiário: Elizabeth Magiolo Coser
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 21/00171-6 - Caracterização funcional de um transportador de fosfolipídios de Leishmania braziliensis: investigação do possível envolvimento na suscetibilidade à miltefosina
• Beneficiário: Cristiele Saborito da Silva
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 16/21171-6 - Paromomicina no tratamento da Leishmaniose Tegumentar: investigação in vitro, in vivo e na identificação de marcadores moleculares associados à suscetibilidade e resistência
• Beneficiário: Adriano Cappellazzo Coelho
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores