| Texto completo | |
| Autor(es): |
Hamed, Abdelaaty
;
El Gaafary, Menna
;
Fumiko Yamaguchi, Lydia
;
Stammler, Hans Georg
;
Salih, Layth M.
;
Ziegler, David
;
Syrovets, Tatiana
;
Kato, Massuo Jorge
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NATURAL PRODUCT RESEARCH; v. N/A, p. 7-pg., 2024-09-13. |
| Resumo | |
Chromatographic fractionation of CH2Cl2:MeOH (1:1) extract of Coccoloba peltata Schott cultivated in Egypt afforded four compounds, lupeol acetate (1), ent-13-epi-manoyl oxide (2), 5-methoxymethyl-7,8-dimethyltocol (3), and alpha-tocopherol quinone (4). The planar structures of the isolated compounds were concluded based on HRESIMS and NMR spectroscopy. X-ray crystallography of 2 is reported herein for the first time and its unambiguous absolute configuration was deduced from anomalous dispersion. To the best of our knowledge, this is the first known report on the isolation of compounds 1-4 from this species. Among the isolated compounds, only compound 4 showed a moderate level of cytotoxic activity against six cancer cell lines out of seven cell lines tested. [GRAPHICS] (AU) | |
| Processo FAPESP: | 18/07999-7 - VIDA-FROG: valorização de moléculas isoladas de anfíbios portugueses |
| Beneficiário: | Massuo Jorge Kato |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 19/27661-3 - Peptídeos bioativos de anfíbios portugueses |
| Beneficiário: | Abdelaaty Hamed Abdelaaty Mona |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 14/50316-7 - Dimensões US-BIOTA São Paulo: diversidade de interações multi-tróficas quimicamente mediadas em gradientes nos trópicos |
| Beneficiário: | Massuo Jorge Kato |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Temático |