| Texto completo | |
| Autor(es): |
Xavier, Gabriela
;
Mauer, Jessica
;
Ota, Vanessa K.
;
Santoro, Marcos L.
;
Belangero, Sintia I.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF PSYCHIATRIC RESEARCH; v. 176, p. 10-pg., 2024-06-12. |
| Resumo | |
Schizophrenia (SCZ) is a severe psychiatric disorder with unclear pathophysiology. Moreover, there is no specific biological marker to help clinicians to define a diagnosis, and medication is decided according to the psychiatrist's experience. In this scenario, microRNAs (miRNAs), which are small noncoding RNA molecules that regulate several genes, emerge as potential peripheral biomarkers to help not only the evaluation of the disease state but also the treatment response. Here, we systematically reviewed indexed literature and evaluated followup studies investigating the changes in miRNA expression due to antipsychotic treatment. We also assessed target genes and performed pathway enrichment analysis of miRNAs listed in this systematic review. A total of 11 studies were selected according to research criteria, and we observed that 28 miRNAs play a relevant role in schizophrenia pathogenesis or response to antipsychotic treatment, seven of those of extreme interest as possible biomarkers either for condition or treatment. Predicted targets of the miRNAs reviewed here were previously associated with schizophrenia in genome-wide studies, and pathway analysis showed enrichment for genes related to neural processes. With this review, we expect to highlight the importance of miRNAs in schizophrenia pathogenesis and its treatment and point out interesting miRNAs to future studies. (AU) | |
| Processo FAPESP: | 20/02247-7 - Expressão de miRNAs de vesículas extracelulares associados ao aparecimento de sintomas psiquiátricos em adolescentes |
| Beneficiário: | Jessica Honorato Mauer |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 16/19462-2 - O papel dos miRNAs na esquizofrenia: do genoma à proteína |
| Beneficiário: | Gabriela Xavier |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 23/05560-6 - Abordagens genéticas e epigenéticas como modelos preditivos em transtornos mentais |
| Beneficiário: | Marcos Leite Santoro |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |