Busca avançada
Ano de início
Entree


Pitfalls in the Diagnostic Evaluation of Pheochromocytomas

Texto completo
Autor(es):
Fagundes, Gustavo F. C. ; Almeida, Madson Q.
Número total de Autores: 2
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF THE ENDOCRINE SOCIETY; v. 8, n. 6, p. 12-pg., 2024-04-06.
Resumo

Pheochromocytomas and paragangliomas (PPGLs), rare neuroendocrine tumors arising from chromaffin cells, present a significant diagnostic challenge due to their clinical rarity and polymorphic symptomatology. The clinical cases demonstrate the importance of an integrated approach that combines clinical assessment, biochemical testing, and imaging to distinguish PPGLs from mimicking conditions, such as obstructive sleep apnea and interfering medication effects, which can lead to false-positive biochemical results. Although a rare condition, false-negative metanephrine levels can occur in pheochromocytomas, but imaging findings can give some clues and increase suspicion for a pheochromocytoma diagnosis. This expert endocrine consult underscores the critical role of evaluating preanalytical conditions and pretest probability in the biochemical diagnosis of PPGLs. Moreover, a careful differentiation of PPGLs from similar conditions and careful selection and interpretation of diagnostic tests, with focus on understanding and reducing false positives to enhance diagnostic accuracy and patient outcomes, is crucial. (AU)

Processo FAPESP: 19/15873-6 - Investigação de novos aspectos genéticos, clínicos e anatomopatológicos da hipertensão arterial de origem endócrina
Beneficiário:Madson Queiroz Almeida
Modalidade de apoio: Auxílio à Pesquisa - Temático