Acute lupus myocarditis: Clinical features and outcome

Autor(es)

Appenzeller, S. ^{[1, 2, 3]} ; Pineau, C. A. ^[4] ; Clarke, A. E. ^{[2, 3]}

Afiliação do(s) autor(es)

^[1] State Univ Campinas UNICAMP, Fac Med Sci, Campinas, SP - Brazil

^[2] McGill Univ, Div Clin Immunol Allergy, Ctr Hlth, Montreal, PQ H3A 2T5 - Canada

^[3] McGill Univ, Div Clin Epidemiol, Ctr Hlth, Montreal, PQ H3A 2T5 - Canada

^[4] McGill Univ, Div Rheumatol, Ctr Hlth, Montreal, PQ H3A 2T5 - Canada

• Tipo de documento: Artigo Científico
• Fonte: Lupus; v. 20, n. 9, p. 981-988, AUG 2011.
• Citações Web of Science: 17

Resumo

Background: Cardiomyopathy in systemic lupus erythematosus (SLE) may be secondary to myocardial inflammation (i.e. myocarditis) or to systemic complications such as hypertension. Symptomatic left ventricular dysfunction is the most common clinical presentation of cardiomyopathy and is potentially life threatening. Identifying the cause is critical as it dictates therapy. Methods: We present three cases of left ventricular failure suggestive of myocarditis in SLE patients followed in the Lupus Clinic of the Montreal General Hospital over a 5-year period. Results: The most frequent presentation is acute onset of a marked reduction of the left ventricular ejection fraction (LVEF). All patients were treated with cardiac support, prednisone, and additional immunosuppressive medications. Improvement of symptoms and LVEF was observed in two of three patients. Conclusion: Myocarditis is a rare, but life-threatening, manifestation of SLE. With immunosuppressive medications and cardiovascular support, the long-term outcome is usually favorable. Lupus (2011) 20, 981-988. (AU)

• Processo FAPESP: 09/06049-6 - Determinação de marcadores séricos e do líquor associados a alterações estruturais e funcionais do sistema nervoso central no Lúpus eritematoso sistêmico
• Beneficiário: Simone Appenzeller
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 08/02917-0 - Determinação de marcadores séricos e do líquor associados a alterações estruturais e funcionais do sistema nervoso central no lúpus eritematoso sistêmico
• Beneficiário: Simone Appenzeller
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores