Refining the circuits of drug addiction: The ventral pallidum

Autor(es)

Morais-Silva, Gessynger ; Lobo, Mary Kay

• Tipo de documento: Artigo Científico
• Fonte: CURRENT OPINION IN NEUROBIOLOGY; v. 86, p. 7-pg., 2024-05-29.

Resumo

The ventral pallidum is a prominent structure within the basal ganglia, regulating reward and motivational processes. Positioned at the interface between motor and limbic structures, its function is crucial to the development and maintenance of substance use disorders. Chronic drug use induces neuroplastic events in this structure, leading to long-term changes in VP neuronal activity and synaptic communication. Moreover, different neuronal populations within the VP drive drug-seeking behavior in opposite directions. This review explores the role of the VP as a hub for reward, motivation, and aversion, establishing it as an important contributor to the pathophysiology of substance use disorders. (AU)

• Processo FAPESP: 18/05496-8 - Papel das projeções pálido ventral-núcleo acumbens na susceptibilidade e resiliência ao estresse de derrota social
• Beneficiário: Gessynger Morais Silva
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 20/15216-2 - Avaliação da conexão inter-hemisférica do córtex pré-frontal medial na resiliência e susceptibilidade ao estresse psicossocial em camundongos fêmeas e machos: porque o lado importa
• Beneficiário: Gessynger Morais Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado