Emerging roles of thiol oxidoreductase-dependent mechanisms on vasomotricity regulation

Autor(es)

Portas, Carolina Morales ; Garcia, Geovana Stefani ; Gaspar, Renato Simoes ; Casagrande, Annelise da Silva ; Tanaka, Leonardo Yuji

• Tipo de documento: Artigo Científico
• Fonte: ADVANCES IN REDOX RESEARCH; v. 6, p. 11-pg., 2022-12-01.

Resumo

Vasomotricity, defined by measurements of contraction or relaxation, is important to support correct blood supply and needs to be finely regulated during hemodynamic changes. Disruptions in either contraction or relaxation, mainly endothelium-mediated, are closely related to cardiovascular diseases and are found during early events of vascular structural alterations, including vessel remodeling. Both acute vasomotor changes and chronic vascular remodeling are regulated by redox processes, such as the production of nitric oxide (NO), which is the major vasoactive endothelium-derived paracrine molecule. However, it is still unclear if vasomotricity can be regulated by direct redox reactions or thiol posttranslational modifications induced by secondary mediators. Here, we have reviewed the literature concerning the control of vascular function based on redox processes and merged evidence with mechanisms supporting structural alterations. Such knowledge is important to summarize the resulting vascular effects that occur upon inhibition of specific redox regulators. This may provide a landscape to better understand the complex redox regulation of vasomotricity and determine a hierarchical map of events involving NO biology, calcium transient regulation, actin cytoskeleton and extracellular matrix organization. In addition, we have proposed that the thiol oxidoreductase protein disulfide isomerase A1 (PDI) has the potential to act as a central hub connecting these processes with local oxidant generation, which may globally impact vascular function in physiologic and pathologic processes. Altogether, the understanding of these redox processes may lead to potential therapeutic redox targets able to prevent or treat functional or structural vascular alterations. (AU)

• Processo FAPESP: 20/04280-1 - Mecanismos subcelulares envolvidos na convergência entre homeostase mecânica e redox na regulação vascular
• Beneficiário: Leonardo Yuji Tanaka
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
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• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/07230-5 - Mecanismos subcelulares envolvidos na convergência entre homeostase mecânica e redox na regulação vascular
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• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
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• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica