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Vieira, Jeniffer
;
de Oliveira, Thiago Vinicius Vieira
;
Queiroz, Lorrayne Rithielle Rocha
;
Camargo, Camila Tussato Soares
;
Nardy, Ariane
;
Monteiro, Fernanda Rodrigues
;
do Amaral, Jonatas Bussador
;
Paixao, Vitoria
;
Vaisberg, Mauro
;
Amirato, Gislene Rocha
;
dos Santos, Carlos Andre Freitas
;
Durigon, Edison Luiz
;
Oliveira, Danielle Bruna Leal
;
Aguiar, Andressa Simoes
;
Alvares-Saraiva, Anuska Marcelino
;
Heller, Debora
;
Mantoanelli, Patricia Gabriela Viana
;
Siqueira, Michelle Foigel
;
Nali, Luiz Henrique da Silva
;
Bachi, Andre Luis Lacerda
Número total de Autores: 20
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| Tipo de documento: | Artigo Científico |
| Fonte: | BMC GERIATRICS; v. 24, n. 1, p. 17-pg., 2024-10-03. |
| Resumo | |
BackgroundAlthough important information concerning COVID-19 vaccination is available, the effects of the CoronaVac and ChadOx-1 vaccines on immunity and the redox balance in the upper airway mucosa of the aged population are not fully understood. Therefore, the aim of this study was to investigate the impacts of two doses of the CoronaVac or ChadOx-1 vaccine on immune/inflammatory responses and oxidative stress in the airway mucosa of older adults.MethodsSeventy-six older adults of both sexes, with a mean age of 75.1 +/- 6.4 years, were separated according to vaccination status into the CoronaVac (n = 52) and ChadOx-1 (n = 24) groups. Saliva samples were collected before (pre) and 30 days after (post) the administration of the second dose of the CoronaVac or ChadOx-1 vaccine to assess the levels of antibodies (sIgA and IgG), antimicrobial peptides, cytokines, and oxidant/antioxidant agents.ResultsThe immunogenicity in the ChadOx-1 group was 37.5% for sIgA and 25% for IgG, while that in the CoronaVac group was 18.9% for sIgA and 13.2% for IgG. Intergroup analysis revealed that (1) lower levels of IFN-alpha, IFN-gamma, and IL-10 and a greater IFN-gamma/IL-10 ratio, in addition to a greater IL-6/IL-10 ratio, were found in both the pre- and postvaccination periods, and (2) lower levels of total sIgA, IL-12p70, IL-17A, TNF-alpha, and the IL-12p70/IL-10 ratio, in addition to higher levels of specific sIgA for SARS-CoV-2 antigens and lysozyme, were observed only in the postvaccination period in the ChadOx-1 group than in the CoronaVac group. Intragroup analysis revealed (1) a significant increase in the salivary levels of total peroxides in the postvaccination period compared to those in the prevaccination period in both volunteer groups; (2) a decrease in the levels of lysozyme and the ratio between total antioxidant capacity (TAC) and total peroxides in the postvaccination period in the CoronaVac group compared with those in the prevaccination period; and (3) decreases in the TNF-alpha, IL-6, and IL-12p70 levels, and the IL-12p70/IL-10 ratio in the ChadoX-1 group, as well as a higher lactoferrin concentration in the postvaccination period than in the prevaccination period. Several positive and negative correlations between the parameters assessed here were found.ConclusionsIn general, the ChadOx-1 group exhibited improvements in both immune/inflammatory responses and redox balance and greater immunogenicity than did the CoronaVac group. (AU) | |
| Processo FAPESP: | 20/16371-1 - Avaliação das alterações na resposta imune/inflamatória presentes na mucosa oral de pacientes idosos co-infectados pelo SARS-COV-2 e citomegalovírus. |
| Beneficiário: | Jeniffer Vieira |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 21/01960-4 - Avaliação das alterações na resposta imune/inflamatória da mucosa nasofaríngea em pacientes idosos co-infectados pelo sars-cov-2 e citomegalovírus. |
| Beneficiário: | Camila Tussato Soares Camargo |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 19/14115-0 - Influência da suplementação de L-glutamina na sarcopenia e resposta imune/inflamatória sistêmica e das vias aéreas de idosos praticantes ou não de um programa regular de exercícios físicos combinados submetidas à vacinação contra o vírus Influenza |
| Beneficiário: | André Luis Lacerda Bachi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |