Anti-leishmanial and anti-trypanosomal potential of polygodial isolated from stem barks of Drimys brasiliensis Miers (Winteraceae)

Autor(es)

Correa, Daniela S. ^[1] ; Tempone, Andre G. ^[1] ; Reimao, Juliana Q. ^[1] ; Taniwaki, Noemi N. ^[1] ; Romoff, Paulete ^{[2, 3]} ; Favero, Oriana A. ^{[2, 3]} ; Sartorelli, Patricia ^[4] ; Mecchi, Murilo C. ^[4] ; Lago, Joao Henrique G. ^[4]

Afiliação do(s) autor(es)

^[1] Inst Adolfo Lutz Registro, Dept Parasitol, Lab Toxinol Aplicada, BR-01246000 Sao Paulo - Brazil

^[2] Univ Presbiteriana Mackenzie, Ctr Ciencias Biol & Saude, BR-01302907 Sao Paulo - Brazil

^[3] Univ Presbiteriana Mackenzie, Ctr Ciencias & Humanidades, BR-01302907 Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Parasitology Research; v. 109, n. 1, p. 231-236, JUL 2011.
• Citações Web of Science: 40

Resumo

Parasitic protozoan diseases affect the poorest population in developing countries. Leishmaniasis and Chagas disease have been included among the most important threats for public health in Central and South American continent, with few therapeutic alternatives and highly toxic drugs. In the course of selection of novel drug candidates, we studied the anti-protozoal potential of Drimys brasiliensis. Thus, the crude hexane extract from stem bark as well as its main derivative, the sesquiterpene polygodial, were tested using in vitro assays. The crude hexane extract and polygodial showed activity against Leishmania spp. in the range between 22 and 62 mu g/mL, but polygodial demonstrated high parasite selectivity towards Trypanosoma cruzi trypomastigotes (2 mu g/mL), with a selectivity index of 19. Finally, polygodial showed a leishmanicidal effect, inducing intense ultrastructural damages in Leishmania in short-time incubation. The obtained results suggested that polygodial could be used as a tool for drug design studies against protozoan diseases and as a candidate molecule for further in vivo studies against T. cruzi. (AU)

• Processo FAPESP: 06/57626-5 - Seleção de moléculas potenciais em espécies vegetais de regiões de altitude do estado de São Paulo: estrutura química, relações estrutura / atividade biológica associadas a considerações ecofisiológicas
• Beneficiário: João Henrique Ghilardi Lago
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores