What we have learned from non-human primates as animal models of epilepsy

Autor(es)

Sanabria, Viviam ; Romariz, Simone A. A. ; Braga, Matheus ; Pires, Jaime Moreira ; Naffah-Mazzacoratti, Maria da Graca ; Mello, Luiz Eugenio ; Longo, Beatriz M. ; Foresti, Maira Licia

• Tipo de documento: Artigo Científico
• Fonte: Epilepsy & Behavior; v. 154, p. 10-pg., 2024-03-21.

Resumo

Non -human primates (NHPs) have played a crucial role in our understanding of epilepsy, given their striking similarities with humans. Through their use, we have gained a deeper understanding of the neurophysiology and pathophysiology of epileptic seizures, and they have proven invaluable allies in developing anti -seizure therapies. This review explores the history of NHPs as natural models of epilepsy, discusses the findings obtained after exposure to various chemoconvulsant drugs and focal electrical stimulation protocols that helped uncover important mechanisms related to epilepsy, examines diverse treatments to prevent and manage epilepsy, and addresses essential ethical issues in research. In this review, we aim to emphasize the important role of NHPs in epilepsy research and summarize the benefits and challenges associated with their use as models. (AU)

• Processo FAPESP: 18/24561-5 - Epileptogênese, biomarcadores e epilepsia pós-traumática
• Beneficiário: Luiz Eugenio Araujo de Moraes Mello
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/05242-3 - Estudo do efeito anticonvulsivo do canabidiol após trauma encefálico
• Beneficiário: Simone Amaro Alves Romariz Bertola
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 22/00249-8 - Avaliação dos efeitos do exercício físico resistido e da indução da amiloidogênese e neuroinflamação em modelos in vivo e in vitro da Doença de Alzheimer
• Beneficiário: Beatriz de Oliveira Monteiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular