| Texto completo | |
| Autor(es): |
Berilli, Patricia
;
Berni, Paulo Roberto de Araujo
;
Zandona, Lais
;
Bellinazzi, Levi Nascimento
;
Marostica Junior, Mario Roberto
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NUTRITION RESEARCH REVIEWS; v. N/A, p. 25-pg., 2025-06-13. |
| Resumo | |
Obesity pathophysiological conditions and obesogenic diet compounds may influence brain function and structure and, ultimately, cognitive processes. Animal models of diet-induced obesity suggest that long-term dietary high fat and/or high sugar may compromise cognitive performance through concomitant peripheral and central disturbances. Some indicated mechanisms underlying this relationship are discussed here: adiposity, dyslipidaemia, inflammatory and oxidative status, insulin resistance, hormonal imbalance, altered gut microbiota and integrity, blood-brain barrier dysfunction, apoptosis/autophagy dysregulation, mitochondrial dysfunction, vascular disturbances, cerebral protein aggregates, impaired neuroplasticity, abnormal neuronal network activity and neuronal loss. Mechanistic insights are vital for identifying potential preventive and therapeutic targets. In this sense, flavonoids have gained attention due to their abundant presence in vegetable and other natural sources, their comparatively negligible adverse effects and their capacity to cross the blood-brain barrier promptly. In recent years, interventions with flavonoid sources have proven to be efficient in restoring cognitive impairment related to obesity. Its modulatory effects occur directly and indirectly into the brain, and three fronts of action are highlighted here: (1) restoring physiological processes altered in obesity; (2) promoting additional neuroprotection to the endogenous system; and (3) improving neuroplasticity mechanisms that improve cognitive performance itself. Therefore, flavonoid consumption is a promising alternative tool for managing brain health and obesity-related cognitive impairment. (AU) | |
| Processo FAPESP: | 22/09493-9 - Estudos in vitro do metaboloma de antocianinas de frutas visando entender seus mecanismos de ação contra a Obesidade |
| Beneficiário: | Juliano Lemos Bicas |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 23/17076-1 - Potencial tecnológico, nutricional e funcional de farinhas de subprodutos da cadeia produtiva de Cambuci (Campomanesia phaea) e maracujá da Caatinga (Passiflora cincinnata Mast.) |
| Beneficiário: | Mário Roberto Maróstica Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 18/11069-5 - Ação de berries brasileiras sobre parâmetros metabólicos e desempenho cognitivo de animais obesos |
| Beneficiário: | Mário Roberto Maróstica Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |