| Texto completo | |
| Autor(es): |
Sawada, Maria Isabela Bloise Alves Caldas
;
Santana, Monique de Fatima de Mello
;
Vancini, Milena Gomes
;
Passarelli, Marisa
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SEMINARS IN CANCER BIOLOGY; v. 114, p. 15-pg., 2025-09-01. |
| Resumo | |
Plasma lipid and lipoprotein profiles are recognized as key modulators in breast cancer (BC) development. Notably, the association between high-density lipoprotein cholesterol (HDLc) and BC remains controversial, with studies reporting positive, negative, or no correlation. This inconsistency may arise from the clinical metrics used to quantify high-density lipoproteins (HDL), such as HDLc and apolipoprotein (apo) A-1, which may not accurately reflect HDL functionality in modulating the tumor microenvironment. Moreover, HDL particles isolated from plasma may undergo modifications influenced by tumor activity, varying with disease stage, severity, and treatment. In this review, we are critically reopening Pandora<acute accent>s box analyzing evidence on HDLc plasma levels and HDL functionality in BC. Specifically, HDL contributes to tumor regulation by removing excess cellular cholesterol, thereby limiting sterol availability for cell replication and metastasis. Additionally, HDL exerts antioxidant and anti-inflammatory effects and acts as a carrier of bioactive proteins, lipids, and microRNAs, facilitating their delivery to target cells and modulating intracellular signaling and gene expression. Collectively, HDL functionality may serve as a predictor of therapeutic response and clinical outcomes in BC. (AU) | |
| Processo FAPESP: | 21/02401-9 - Atividade anti-inflamatória e transporte de microRNA pelas lipoproteínas de densidade alta (HDL) no Câncer de Mama: associação com o prognóstico da doença predito pela classificação molecular do tumor |
| Beneficiário: | Monique de Fatima Mello Santana |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 16/15603-0 - Desvendando mecanismos envolvidos no controle glicêmico e nas complicações crônicas do Diabetes mellitus: contribuições à saúde humana |
| Beneficiário: | Ubiratan Fabres Machado |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/18431-4 - Lipoproteínas de densidade alta, produtos de glicação avançada e óxidos de colesterol no Câncer de Mama: associação com a classificação molecular do tumor e o prognóstico da doença |
| Beneficiário: | Marisa Passarelli |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |