| Texto completo | |
| Autor(es): Mostrar menos - |
Luethi, Matthias S.
;
Borrione, Lucas
;
Cavendish, Beatriz A.
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Aparicio, Luana V. M.
;
Goerigk, Stephan
;
Ramos, Matheus R. F.
;
Moran, Natasha K. S.
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Carneiro, Adriana M.
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Valiengo, Leandro
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Moura, Darin O.
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de Souza, Juliana P.
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Batista, Mariana P.
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da Silva, Valquiria Aparecida
;
Klein, Izio
;
Suen, Paulo
;
Gallucci-Neto, Jose
;
Padberg, Frank
;
Razza, Lais B.
;
Vanderhasselt, Marie-Anne
;
Lotufo, Paulo A.
;
Benseno, Isabela M.
;
Fregni, Felipe
;
Brunoni, Andre R.
Número total de Autores: 23
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| Tipo de documento: | Artigo Científico |
| Fonte: | Revista Brasileira de Psiquiatria; v. 47, p. 7-pg., 2025-01-01. |
| Resumo | |
Objective: Major depressive disorder is heterogeneous. While transcranial direct current stimulation (tDCS) is an effective treatment, its impact on symptoms remains underexplored. This ancillary study investigated the effects of home-use tDCS on depression symptom clusters. Methods: Data were used from the Portable Transcranial Electrical Stimulation and Internet-Based Behavioral Therapy for Major Depression Study (PSYLECT) study, in which 210 depressed patients were randomized to active (n=137) or sham tDCS (n=73) for 6 weeks. Items from the Hamilton Depression Rating Scale were grouped into symptom clusters using hierarchical clustering. Treatment effects were analyzed with mixed regressions. An alternative clustering solution was also evaluated using a larger sample. Results: Four clusters were identified: emotional, sleep, psychomotor, and psychosomatic symptoms. None showed significant group differences (sleep: p = 0.058, Cohen's d = 0.36, emotional: p = 0.976, d = -0.01, psychosomatic: p = 0.157, d = 0.27, psychomotor: p = 0.944, d = 0.01). The alternative clustering solution produced a similar sleep cluster, where tDCS led to significant reductions (p = 0.033, d = 0.41), but no differences were observed in other clusters (emotional: p = 0.707, d = 0.07, atypical: p = 0.537, d = 0.12). Conclusion: The association between tDCS and sleep improvement warrants further study. tDCS may be more effective for specific symptom clusters. (AU) | |
| Processo FAPESP: | 21/10574-0 - Aumento de acurácia prognóstica em pacientes deprimidos utilizando diferentes intervenções de neuromodulação não-implantáveis |
| Beneficiário: | Matthias Stephan Luthi |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 19/06009-6 - Terapias de neuromodulação não-implantáveis: uma perspectiva para o cérebro deprimido |
| Beneficiário: | Geraldo Busatto Filho |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |