| Texto completo | |
| Autor(es): |
da Silva, Pedro Henrique Rodrigues
;
Vanderhasselt, Marie-Anne
;
Pilloni, Giuseppina
;
Charvet, Leigh
;
Padberg, Frank
;
Bikson, Marom
;
Brunoni, Andre R.
;
Razza, Lais B.
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Revista Brasileira de Psiquiatria; v. 47, p. 12-pg., 2025-01-01. |
| Resumo | |
Objective: Depression is a common and debilitating disorder affecting millions of people. First-line treatments fail to achieve remission in approximately one-third of patients, highlighting a critical need for treatment. Transcranial direct current stimulation (tDCS) has emerged as a novel treatment for depression. Therefore, the aim of this review was to provide a comprehensive overview of the last decade of tDCS trials for depression and to suggest future research directions. Methods: To synthesize studies from the past decade, we conducted a systematic review and metaanalysis of randomized clinical trials (RCTs) of tDCS for depression. Results: A total of 21 RCTs were included, showing a moderate effect of active tDCS compared to placebo. We also provided a description of study designs, stimulation parameters, and patient characteristics. We then proposed possible strategies to improve clinical efficacy and reduce outcome variability, including 1) optimization/personalization of tDCS through spatial and temporal target and novel study designs, and 3) investigation of the patient profile to identify characteristics that may Conclusion: tDCS shows promise as a treatment for depression, but variability in study parameters and outcomes underscores the need for further optimization. Refinement and standardization of protocols may improve its efficacy. (AU) | |
| Processo FAPESP: | 22/03266-0 - Investigação de avaliações de neuroimagem e modelagem de fluxo de corrente como biomarcadores de engajamento alvo e preditores de terapias convulsivas |
| Beneficiário: | Pedro Henrique Rodrigues da Silva |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 18/10861-7 - Avaliação multimodal dos efeitos da estimulação transcraniana por corrente contínua e estimulação theta-burst no funcionamento do córtex pré-frontal: um estudo Fase-I bilateral, placebo-controlado, fatorial |
| Beneficiário: | Andre Russowsky Brunoni |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 19/06009-6 - Terapias de neuromodulação não-implantáveis: uma perspectiva para o cérebro deprimido |
| Beneficiário: | Geraldo Busatto Filho |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |