The role of eosinophils and eosinophil cationic protein in oral cancer: A review

Autor(es)

Pereira, Michele Conceicao ^{[1, 2]} ; Oliveira, Denise Tostes ^[1] ; Kowalski, Luiz Paulo ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Sao Paulo - Brazil

^[2] Univ Fed Sao Joao del Rei, Minas Gerais - Brazil

^[3] Canc Hosp AC Camargo, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: ARCHIVES OF ORAL BIOLOGY; v. 56, n. 4, p. 353-358, APR 2011.
• Citações Web of Science: 16

Resumo

Eosinophils are multifunctional leukocytes implicated in the pathogenesis of numerous inflammatory processes, such as allergies and parasitic infections. Increased number of these cells has been described in many human cancers, including oral squamous cell carcinoma, and its presence related to favourable as well as unfavourable prognosis. Although the exact role of eosinophils in tumours is not yet defined, the anti-tumour activity of these rare granulocytes has been associated with the release of their cytotoxic proteins, especially the eosinophil cationic protein, a single polypeptide chain with a molecular mass ranging from 15 to 22 kDa encoded by the RNSE3 gene located on chromosome 14q11.2. Functional studies have implicated ECP in numerous processes, such as tissue remodelling in allergic inflammation; however its most striking function is the cytotoxic activity. The aim of this review is to summarise the role and functions of eosinophils and their granule-derived products in oral malignant tumours and the clinical value of the tumour-associated tissue eosinophilia for patients' prognosis. (C) 2010 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 06/03830-0 - Associação do polimorfismo do gene da proteína catiônica eosinofílica com a eosinofilia tecidual associada aos tumores em carcinomas espinocelulares de boca
• Beneficiário: Denise Tostes Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular