| Texto completo | |
| Autor(es): |
Nunes Filho, Dilson Marreiros
;
Aikawa, Nadia Emi
;
Kupa, Leonard de Vinci Kanda
;
Pasoto, Sandra Gofinet
;
Seguro, Luciana Parente Costa
;
Yuki, Emily Figueiredo Neves
;
Lopes, Michelle Remiao Ugolini
;
Silva, Clovis Artur
;
Bonfa, Eloisa Silva Dutra de Oliveira
;
Neto, Eduardo Ferreira Borba
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Lupus; v. N/A, p. 8-pg., 2025-12-27. |
| Resumo | |
Objective To evaluate whether hydroxychloroquine (HCQ) dose reduction (2-3 mg/kg/day) sustain lipoprotein levels achieved with higher doses of 2016-American Academy of Ophthalmology (2016-AAO) in stable lupus nephritis (LN) patients.Methods Forty-seven consecutive stable LN patients using HCQ 2016-AAO recommended dose for >= 6 months were enrolled and assigned to one of two groups: Reduced HCQ group (n = 21):LN patients who, upon inclusion, reduced 2016-AAO dose (2-3 mg/kg/day); and Maintenance HCQ group (n = 26):LN patients who continued on the standard 2016-AAO recommended HCQ dose (4.0-5.5 mg/kg actual body weight, maximum 400 mg/day) throughout 12-month study period. Blood HCQ levels, lipid profile and SLE parameters (including SLEDAI-2K) were assessed at baseline, 3 and 12-month.Results Baseline demographics, comorbidities and disease parameters were similar among groups (p > .05). Initial blood levels of Reduced HCQ group were 1219.4 (1041.7-1926.6)ng/mL and a progressive significant decrease were identified after 3 and 12 months [651.2 (538.4-832.6)vs.468.8 (228.4-925.6)ng/mL, p < .001]. Maintenance HCQ group had no changes in HCQ levels during the study [1179.7 (905.5-1607.3)vs.1026.2 (710.5-1345.8)vs.907.9 (663.9-1304.2)ng/mL, p = .158]. No changes were observed on the longitudinal total cholesterol levels of Reduced HCQ [166 (113-198)vs.153 (85-192)vs.150 (90-231)mg/dL, p = .964] and Maintenance HCQ [155 (114-244)vs.154 (122-210)vs.155 (112-213)mg/dL, p = .395]. LDL cholesterol levels of Reduced HCQ [91 (52-163)vs.83 (41-136vs.87 (47-165)mg/dL, p = .917] and Maintenance HCQ [79 (36-114)vs.76.5 (33-111)vs.75.5 (63-131)mg/dL, p = .412] remained similar. Other lipoprotein levels remained stable during 1 year of study.Conclusion This is the first study to show that reducing HCQ to 2-3 mg/kg/day preserves lipid stability over 12 months in stable lupus nephritis patients. (AU) | |
| Processo FAPESP: | 15/03756-4 - Avaliação da relevância dos níveis sanguíneos de drogas utilizadas em doenças autoimunes reumatológicas no acompanhamento da segurança, eficácia e aderência à terapêutica |
| Beneficiário: | Eloisa Silva Dutra de Oliveira Bonfá |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |