Role of ultrasound, clinical and scintigraphyc parameters to predict malignancy in thyroid nodule

Autor(es)

Maia, Frederico F. R. ^[1] ; Matos, Patricia S. ^[2] ; Silva, Bradley P. ^[1] ; Pallone, Ana T. ^[1] ; Pavin, Elizabeth J. ^[1] ; Vassallo, Jose ^[2] ; Zantut-Wittmann, Denise E. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Internal Med, Div Endocrinol, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Dept Pathol, Sch Med Sci, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: HEAD & NECK ONCOLOGY; v. 3, MAR 22 2011.
• Citações Web of Science: 22

Resumo

Background: This study aimed to evaluate clinical, laboratory, ultrasound (US) and scintigraphyc parameters in thyroid nodule and to develop an auxiliary model for clinical application in the diagnosis of malignancy. Methods: We assessed 143 patients who were surgically treated at a single center, 65% (93) benign vs. 35% (50) malignant lesions at final histology (1998-2008). The clinical, laboratory, scintigraphyc and US features were compared and a prediction model was designed after the multivariate analysis. Results: There were no differences in gender, serum TSH and FT4 levels, thyroid auto-antibodies (TAb), thyroid dysfunction and scintigraphyc results (P = 0.33) between benign and malignant nodule groups. The sonographic study showed differences when the presence of suspected characteristics was found in the nodules of the malignant lesions group, such as: microcalcifications, central flow, border irregularity and hypoechogenicity. After the multivariate analysis the model obtained showed age (>39 years), border irregularity, microcalcifications and nodule size over 2 cm as predictive factors of malignancy, featuring 81.7% of accuracy. Conclusions: This study confirmed a significant increase of risk for malignancy in patients of over 39 years and with suspicious features at US. (AU)

• Processo FAPESP: 08/10183-7 - Mecanismos de proliferação celular, apoptose e angiogênese em nódulo de tireóide: correlação clínica, ultrassonográfica, cintilográfica e cito-patológica
• Beneficiário: Denise Engelbrecht Zantut Wittmann
• Modalidade de apoio: Auxílio à Pesquisa - Regular