Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of ultrasound, clinical and scintigraphyc parameters to predict malignancy in thyroid nodule

Full text
Author(s):
Maia, Frederico F. R. [1] ; Matos, Patricia S. [2] ; Silva, Bradley P. [1] ; Pallone, Ana T. [1] ; Pavin, Elizabeth J. [1] ; Vassallo, Jose [2] ; Zantut-Wittmann, Denise E. [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Dept Internal Med, Div Endocrinol, Sao Paulo - Brazil
[2] Univ Estadual Campinas, Dept Pathol, Sch Med Sci, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: HEAD & NECK ONCOLOGY; v. 3, MAR 22 2011.
Web of Science Citations: 22
Abstract

Background: This study aimed to evaluate clinical, laboratory, ultrasound (US) and scintigraphyc parameters in thyroid nodule and to develop an auxiliary model for clinical application in the diagnosis of malignancy. Methods: We assessed 143 patients who were surgically treated at a single center, 65% (93) benign vs. 35% (50) malignant lesions at final histology (1998-2008). The clinical, laboratory, scintigraphyc and US features were compared and a prediction model was designed after the multivariate analysis. Results: There were no differences in gender, serum TSH and FT4 levels, thyroid auto-antibodies (TAb), thyroid dysfunction and scintigraphyc results (P = 0.33) between benign and malignant nodule groups. The sonographic study showed differences when the presence of suspected characteristics was found in the nodules of the malignant lesions group, such as: microcalcifications, central flow, border irregularity and hypoechogenicity. After the multivariate analysis the model obtained showed age (>39 years), border irregularity, microcalcifications and nodule size over 2 cm as predictive factors of malignancy, featuring 81.7% of accuracy. Conclusions: This study confirmed a significant increase of risk for malignancy in patients of over 39 years and with suspicious features at US. (AU)

FAPESP's process: 08/10183-7 - Markers of cell proliferation, apoptosis and angiogenesis in thyroid nodule: correlation between clinical, ultrasonography, thyroid scan and cito-pathology parameters
Grantee:Denise Engelbrecht Zantut Wittmann
Support Opportunities: Regular Research Grants