| Texto completo | |
| Autor(es): |
Kanashiro, Alexandre
;
Medeiros, Priscila
;
Medeiros, Ana Carolina
;
Ferreira, Frederico Rogerio
;
Campos, Alline Cristina de
;
Barichello, Tatiana
;
Coimbra, Norberto Cysne
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Neuroscience Letters; v. 870, p. 8-pg., 2025-11-16. |
| Resumo | |
Depression is a debilitating psychiatric illness, and its etiology as well as resistance to current pharmacological treatments are increasingly associated with low-grade inflammation. Environmental enrichment (EE), a paradigm that combines sensory and cognitive stimulation, social interaction, and voluntary physical activity, has been widely used to alleviate depression-like behaviours in rodent models, focusing on exposure to psychosocial stressors. However, the potential benefits of EE against depression-like behaviours triggered by immune activation remain unexplored. In this study, male C57BL/6 mice were housed under standard conditions or in EE. After six weeks, mice received an intraperitoneal injection of either physiological saline (vehicle) or lipopolysaccharide (LPS), a potent immunologic stimulus. Twenty-four hours later, anhedonia and behavioural despair were evaluated using the tail suspension test (i.e., frequency, latency, and time of immobility) and the splash test (i.e., latency, frequency, and time of grooming), respectively. LPS administration induced behavioural alterations consistent with depression-like behaviours characterised by increased immobility and decreased grooming. Remarkably, EE exposure prevented the development of LPS-induced depression-like behaviours in the tail suspension test and improved specific parameters in the splash test. Taken together, these findings highlight the therapeutic potential of EE as a non-pharmacological strategy for preventing or alleviating immune system activation-associated depression. (AU) | |
| Processo FAPESP: | 11/20343-4 - Via colinérgica anti-inflamatória: o papel da neuroimunomodulação no controle da resposta inflamatória |
| Beneficiário: | Alexandre Kanashiro |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 13/08216-2 - CPDI - Centro de Pesquisa em Doenças Inflamatórias |
| Beneficiário: | Fernando de Queiroz Cunha |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 21/14073-6 - Validação de teste de resiliência emocional usando um paradigma de realidade virtual de medo associado a variáveis autonômicas |
| Beneficiário: | Norberto Cysne Coimbra |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/13560-5 - Efeito da estimulação cerebral profunda (DBS) e do tratamento com canabidiol no núcleo Subtalâmico sobre a modulação dos sintomas motores e não-motores em um modelo experimental de Doença de Parkinson |
| Beneficiário: | Priscila Medeiros de Freitas |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |