Expression of Utrophin at Dystrophin-Deficient Neuromuscular Synapses of mdx Mice: A Study of Protected and Affected Muscles

Autor(es)

Ferretti, Renato ^[1] ; Santo Neto, Humberto ^[1] ; Marques, Maria Julia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Anat Biol Celular Fisiol & Biofis, Inst Biol, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology; v. 294, n. 2, p. 283-286, FEB 2011.
• Citações Web of Science: 4

Resumo

In mdx mice, intrinsic laryngeal muscles are spared and sternomastoid muscles are affected, showing cycles of muscle regeneration. We observed that utrophin and acetylcholine receptors are fragmented only in affected muscles, providing further evidence that changes in the overall distribution of molecules at dystrophic neuromuscular junctions may be correlated with muscle regeneration. Anat Rec, 294:283-286, 2011. (C) 2010 Wiley-Liss, Inc. (AU)

• Processo FAPESP: 08/58491-1 - Mecanismos de proteção da distrofia muscular: estudo proteômico e terapia farmacológica
• Beneficiário: Maria Julia Marques
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 04/15526-9 - Proteínas reguladoras do cálcio e proteção à mionecrose na distrofia muscular de Duchenne
• Beneficiário: Maria Julia Marques
• Modalidade de apoio: Auxílio à Pesquisa - Regular