Inflammatory Mediators Gene Polymorphisms in Preeclampsia

Autor(es)

Franchim, Camila S. ^[1] ; Sass, Nelson ^[1] ; Mattar, Rosiane ^[1] ; Pendeloski, Karen P. T. ^[1] ; Lin, Lawrence Hsu ^[1] ; Torloni, Maria R. ^[1] ; Daher, Silvia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Obstet, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: HYPERTENSION IN PREGNANCY; v. 30, n. 3, p. 338-346, 2011.
• Citações Web of Science: 10

Resumo

Objective. To assess a possible relation between proinflammatory mediators (IL-1R1, IL-12, IL-18, TLR-2, and TLR-4) gene polymorphisms and preeclampsia (PE). Methods. Genotyping was performed on 109 preeclamptic patients and 174 healthy fertile women with at least two previous successful pregnancies (controls). chi(2) or Fisher's exact test were used to compare genotype frequencies. The control group included 174 pregnant women matched by race to the study group. Results. Genotypic and allelic distributions for all six polymorphisms were similar between the study and control groups. IL-1R1 (PstI, rs2234650): p = 0.82; IL-12 (+1188, rs3212227): p = 0.93; IL-18 (-137, rs187238): p = 0.74; IL-18 (-607, rs1946519): p = 0.22; TLR-2 (+2258, rs5743708): p = 0.97; and TLR-4 (+896, rs4986790): p = 0.23. Conclusion. The analyzed gene polymorphisms are not associated with PE. (AU)

• Processo FAPESP: 07/56791-5 - Mediadores de inflamacao e pre-eclampsia: analise de polimorfismos de genes codificadores de il-1r1, il-12, il-18, tlr-2 e tlr-4.
• Beneficiário: Camila Sommerauer Franchim
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/57446-0 - Polimorfismos genéticos e a suscetibilidade à pré-eclâmpsia
• Beneficiário: Silvia Daher
• Modalidade de apoio: Auxílio à Pesquisa - Regular