Odor cues from tumor-bearing mice induces neuroimmune changes

Autor(es)

Alves, Glaucie Jussilane ; Vismari, Luciana ; Lazzarini, Ricardo ; Bernardino Merusse, Jose Luis ; Palermo-Neto, Joao ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Vet Med, Neuroimmunomodulat Res Grp, Dept Phathol, Fac Med Vet & Zootecnia, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Behavioural Brain Research; v. 214, n. 2, p. 357-367, DEC 10 2010.
• Citações Web of Science: 13

Resumo

Cohabitation for 14 days with an Ehrlich tumor-bearing mice was shown, among others, to increase locomotor activity, and hypothalamic noradrenaline levels and turnover, to decrease the innate immune responses and animal resistance to tumor growth. The present experiment was designed to access the relevance of tactile, olfactory, and visual communication to the neuroimmune changes induced by cohabitation with a tumor-bearing partner. Mice that were not allowed to perceive odor cues from their sick partners presented no alterations in neutrophil activity, a fact not observed after visual deprivation and physical isolation. Mice use scents for intraspecies communication in many social contexts. Tumors produce volatile organic compounds released into the atmosphere through breath, sweat, and urine. The present results strongly suggest that volatile compounds released by Ehrlich tumor-injected mice are perceived by their conspecifics, inducing the neuroimmune changes reported for cohabitation with a sick companion. (C) 2010 Published by Elsevier B.V. (AU)

• Processo FAPESP: 04/14128-0 - Neuroimunomodulação: efeitos do estresse e de citocinas nas relações bidirecionais entre os sistemas nervosos central e imune
• Beneficiário: João Palermo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 99/04228-7 - Neuroimunomodulação: efeito do estresse e de fármacos com ação no sistema nervoso central sobre a resposta imune/inflamatória
• Beneficiário: João Palermo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático