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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Odor cues from tumor-bearing mice induces neuroimmune changes

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Alves, Glaucie Jussilane ; Vismari, Luciana ; Lazzarini, Ricardo ; Bernardino Merusse, Jose Luis ; Palermo-Neto, Joao [1]
Total Authors: 5
[1] Univ Sao Paulo, Sch Vet Med, Neuroimmunomodulat Res Grp, Dept Phathol, Fac Med Vet & Zootecnia, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Behavioural Brain Research; v. 214, n. 2, p. 357-367, DEC 10 2010.
Web of Science Citations: 13

Cohabitation for 14 days with an Ehrlich tumor-bearing mice was shown, among others, to increase locomotor activity, and hypothalamic noradrenaline levels and turnover, to decrease the innate immune responses and animal resistance to tumor growth. The present experiment was designed to access the relevance of tactile, olfactory, and visual communication to the neuroimmune changes induced by cohabitation with a tumor-bearing partner. Mice that were not allowed to perceive odor cues from their sick partners presented no alterations in neutrophil activity, a fact not observed after visual deprivation and physical isolation. Mice use scents for intraspecies communication in many social contexts. Tumors produce volatile organic compounds released into the atmosphere through breath, sweat, and urine. The present results strongly suggest that volatile compounds released by Ehrlich tumor-injected mice are perceived by their conspecifics, inducing the neuroimmune changes reported for cohabitation with a sick companion. (C) 2010 Published by Elsevier B.V. (AU)

FAPESP's process: 99/04228-7 - Neuroimmunomodulation: effects of stress and central nervous system acting drugs on immune/inflamatory response
Grantee:João Palermo Neto
Support type: Research Projects - Thematic Grants
FAPESP's process: 04/14128-0 - Neuroimmunomodulation: effects of drugs, stress and cytocines on central nervous and immune systems bidirectional relationships
Grantee:João Palermo Neto
Support type: Research Projects - Thematic Grants