Influence of body composition on bone mass in postmenopausal osteoporotic women

Autor(es)

Genaro, Patricia S. ^[1] ; Pereira, Giselle A. P. ^[1] ; Pinheiro, Marcelo M. ^[2] ; Szejnfeld, Vera L. ^[2] ; Martini, Ligia A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Div Rheumatol, BR-04023900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF GERONTOLOGY AND GERIATRICS; v. 51, n. 3, p. 295-298, NOV-DEC 2010.
• Citações Web of Science: 44

Resumo

We aimed at evaluating the relationship of lean and fat mass to bone mass in osteoporotic postmenopausal women. We invited 65 women who were being treated at the Sao Paulo Hospital osteoporosis outpatients' clinic to participate. Body composition and bone mineral density (BMD) measurements were performed using Dual-energy X-ray absorptiometry methodology (DXA). The mean age and weight were 69.7 +/- 6.4 years and 56.3 +/- 7.6 kg, respectively. Accordingly to the body mass index (BMI), 52.8% were of normal weight and 47.1% of the patients were overweight. Overweight women had significantly higher bone mass. Similarly, skeletal muscle index (SMI) showed a positive effect on BMD measurements and women with sarcopenia had significantly lower BMD measurements in total femur and femoral neck. In multiple regression analysis only lean mass and age, after adjustments to fat mass and BMI, were able to predict total body bone mineral content (BMC) (R(2) = 28%). Also lean mass adjusted to age and BMI were able to predict femoral neck BMD (R(2) = 14%). On the other hand, none of the components of the body composition (lean mass or fat mass) contributed significantly to explaining total femur BMD and neither body composition measurements were associated with spine BMD. These findings suggest that lean mass has a relevant role in BMC and BMD measurements. In addition, lower BMI and lean mass loss (sarcopenia) is associated to lower BMC and BMD of femoral neck and total femur and possible higher risk of osteoporotic fracture. (C) 2010 Elsevier Ireland Ltd. All rights reserved. (AU)

• Processo FAPESP: 03/06238-7 - Efeito da terapia nutricional em pacientes com doenças ósseas-metabólicas e investigação da relação entre nutrientes e marcadores bioquímicos do metabolismo ósseo
• Beneficiário: Lígia Araújo Martini
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 03/10314-0 - Intervenção nutricional em mulheres com osteoporose na pós-menopausa e sua associação com marcadores bioquímicos do metabolismo ósseo e composição corporal
• Beneficiário: Patrícia de Souza Genaro
• Modalidade de apoio: Bolsas no Brasil - Mestrado