Protease-activated Receptor-2 (PAR(2)) in Human Periodontitis

Autor(es)

Holzhausen, M. ^[1] ; Cortelli, J. R. ^[1] ; Araujo da Silva, V. ^[1] ; Nobre Franco, G. C. ^[1] ; Cavalca Cortelli, S. ^[1] ; Vergnolle, N. ^{[2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Stomatol, Sch Dent, Div Periodont, BR-05508000 Sao Paulo - Brazil

^[2] Ctr Physiopathol Toulouse Purpan, INSERM, U563, F-31300 Toulouse - France

^[3] Univ Toulouse 3, F-31000 Toulouse - France

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF DENTAL RESEARCH; v. 89, n. 9, p. 948-953, SEP 2010.
• Citações Web of Science: 29

Resumo

No evidence for the role of protease-activated receptor-2 (PAR(2)) in human periodontal disease has been demonstrated so far. Thus, we sought to investigate the expression of PAR(2) mRNA in chronic periodontitis, and to examine whether its expression is related to the presence of PAR(2) potential activators. Microbiological and gingival crevicular fluid samples were collected from individuals with chronic periodontitis and control individuals, and the presence of neutrophil serine proteinase 3 (P3) and Porphyromonas gingivalis was evaluated. PAR(2) mRNA expression was higher (p < 0.001) in those with chronic periodontitis compared with control individuals, and it was statistically decreased (p = 0.0006) after periodontal treatment. Furthermore, those with chronic periodontitis presented higher (p < 0.05) levels of IL-1 alpha, IL-6, IL-8, and TNF-alpha, total proteolytic activity, P. gingivalis prevalence, and P3mRNA expression compared with control individuals. We conclude that PAR(2) mRNA expression and its potential activators are elevated in human chronic periodontitis, therefore suggesting that PAR(2) may play a role in periodontal inflammation. (AU)

• Processo FAPESP: 07/50665-8 - Associação do receptor tipo 2 ativado por protease (PAR2) com a doença periodontal em humanos
• Beneficiário: Marinella Holzhausen Caldeira
• Modalidade de apoio: Auxílio à Pesquisa - Regular