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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Protease-activated Receptor-2 (PAR(2)) in Human Periodontitis

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Author(s):
Holzhausen, M. [1] ; Cortelli, J. R. [1] ; Araujo da Silva, V. [1] ; Nobre Franco, G. C. [1] ; Cavalca Cortelli, S. [1] ; Vergnolle, N. [2, 3]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Dept Stomatol, Sch Dent, Div Periodont, BR-05508000 Sao Paulo - Brazil
[2] Ctr Physiopathol Toulouse Purpan, INSERM, U563, F-31300 Toulouse - France
[3] Univ Toulouse 3, F-31000 Toulouse - France
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF DENTAL RESEARCH; v. 89, n. 9, p. 948-953, SEP 2010.
Web of Science Citations: 29
Abstract

No evidence for the role of protease-activated receptor-2 (PAR(2)) in human periodontal disease has been demonstrated so far. Thus, we sought to investigate the expression of PAR(2) mRNA in chronic periodontitis, and to examine whether its expression is related to the presence of PAR(2) potential activators. Microbiological and gingival crevicular fluid samples were collected from individuals with chronic periodontitis and control individuals, and the presence of neutrophil serine proteinase 3 (P3) and Porphyromonas gingivalis was evaluated. PAR(2) mRNA expression was higher (p < 0.001) in those with chronic periodontitis compared with control individuals, and it was statistically decreased (p = 0.0006) after periodontal treatment. Furthermore, those with chronic periodontitis presented higher (p < 0.05) levels of IL-1 alpha, IL-6, IL-8, and TNF-alpha, total proteolytic activity, P. gingivalis prevalence, and P3mRNA expression compared with control individuals. We conclude that PAR(2) mRNA expression and its potential activators are elevated in human chronic periodontitis, therefore suggesting that PAR(2) may play a role in periodontal inflammation. (AU)