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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects

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Autor(es):
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Lira, Fabio S. [1] ; Rosa, Jose C. [1] ; Pimentel, Gustavo D. [1] ; Souza, Helio A. [2] ; Caperuto, Erico C. [3] ; Carnevali, Jr., Luiz C. [2] ; Seelaender, Marilia [2] ; Damaso, Ana R. [4] ; Oyama, Lila M. [4, 1] ; de Mello, Marco T. [5] ; Santos, Ronaldo V. [4]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Physiol, Div Nutr, Sao Paulo - Brazil
[2] Univ Sao Paulo, Canc Metab Grp, Inst Biomed Sci, Dept Cell & Dev Biol, BR-05508 Sao Paulo - Brazil
[3] Univ Prebiteriana Mackenzie, Dept Phys Educ, Biol & Hlth Sci Ctr, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Dept Biosci, Sao Paulo - Brazil
[5] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: LIPIDS IN HEALTH AND DISEASE; v. 9, AUG 4 2010.
Citações Web of Science: 45
Resumo

Introduction: A sedentary lifestyle increases the risk of developing cardiovascular disease, obesity, and diabetes. This phenomenon is supported by recent studies suggesting a chronic, low-grade inflammation status. Endotoxin derived from gut flora may be key to the development of inflammation by stimulating the secretion of inflammatory factors. This study aimed to examine plasma inflammatory markers and endotoxin levels in individuals with a sedentary lifestyle and/or in highly trained subjects at rest. Methods: Fourteen male subjects (sedentary lifestyle n = 7; highly trained subjects n = 7) were recruited. Blood samples were collected after an overnight fast (similar to 12 h). The plasmatic endotoxin, plasminogen activator inhibitor type-1 (PAI-1), monocyte chemotactic protein-1 (MCP1), ICAM/CD54, VCAM/CD106 and lipid profile levels were determined. Results: Endotoxinemia was lower in the highly trained subject group relative to the sedentary subjects (p < 0.002). In addition, we observed a positive correlation between endotoxin and PAI-1 (r = 0.85, p < 0.0001), endotoxin and total cholesterol (r = 0.65; p < 0.01), endotoxin and LDL-c (r = 0.55; p < 0.049) and endotoxin and TG levels (r = 0.90; p < 0.0001). The plasma levels of MCP-1, ICAM/CD54 and VCAM/CD106 did not differ. Conclusion: These results indicate that a lifestyle associated with high-intensity and high-volume exercise induces favorable changes in chronic low-grade inflammation markers and may reduce the risk for diseases such as obesity, diabetes and cardiovascular diseases. (AU)

Processo FAPESP: 08/03533-1 - Efeitos do treinamento físico extenuante sobre a expressão gênica de citocinas e seus receptores no eixo hipotálamo-hipófise-adrenal
Beneficiário:Ronaldo Vagner Thomatieli dos Santos
Modalidade de apoio: Auxílio à Pesquisa - Regular