Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects

Author(s):Show less -

Lira, Fabio S. ^[1] ; Rosa, Jose C. ^[1] ; Pimentel, Gustavo D. ^[1] ; Souza, Helio A. ^[2] ; Caperuto, Erico C. ^[3] ; Carnevali, Jr., Luiz C. ^[2] ; Seelaender, Marilia ^[2] ; Damaso, Ana R. ^[4] ; Oyama, Lila M. ^{[4, 1]} ; de Mello, Marco T. ^[5] ; Santos, Ronaldo V. ^[4]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Physiol, Div Nutr, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Canc Metab Grp, Inst Biomed Sci, Dept Cell & Dev Biol, BR-05508 Sao Paulo - Brazil

^[3] Univ Prebiteriana Mackenzie, Dept Phys Educ, Biol & Hlth Sci Ctr, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Dept Biosci, Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil

• Document type: Journal article
• Source: LIPIDS IN HEALTH AND DISEASE; v. 9, AUG 4 2010.
• Web of Science Citations: 45

Abstract

Introduction: A sedentary lifestyle increases the risk of developing cardiovascular disease, obesity, and diabetes. This phenomenon is supported by recent studies suggesting a chronic, low-grade inflammation status. Endotoxin derived from gut flora may be key to the development of inflammation by stimulating the secretion of inflammatory factors. This study aimed to examine plasma inflammatory markers and endotoxin levels in individuals with a sedentary lifestyle and/or in highly trained subjects at rest. Methods: Fourteen male subjects (sedentary lifestyle n = 7; highly trained subjects n = 7) were recruited. Blood samples were collected after an overnight fast (similar to 12 h). The plasmatic endotoxin, plasminogen activator inhibitor type-1 (PAI-1), monocyte chemotactic protein-1 (MCP1), ICAM/CD54, VCAM/CD106 and lipid profile levels were determined. Results: Endotoxinemia was lower in the highly trained subject group relative to the sedentary subjects (p < 0.002). In addition, we observed a positive correlation between endotoxin and PAI-1 (r = 0.85, p < 0.0001), endotoxin and total cholesterol (r = 0.65; p < 0.01), endotoxin and LDL-c (r = 0.55; p < 0.049) and endotoxin and TG levels (r = 0.90; p < 0.0001). The plasma levels of MCP-1, ICAM/CD54 and VCAM/CD106 did not differ. Conclusion: These results indicate that a lifestyle associated with high-intensity and high-volume exercise induces favorable changes in chronic low-grade inflammation markers and may reduce the risk for diseases such as obesity, diabetes and cardiovascular diseases. (AU)

• FAPESP's process: 08/03533-1 - Effect of exhaustive physical training upon citokines and receptors expression in hypothalamus-hipofise-adrenal axis
• Grantee: Ronaldo Vagner Thomatieli dos Santos
• Support Opportunities: Regular Research Grants