Advanced search
Start date

Physical exercise as a non-pharmacological strategy in the prevention and treatment of Alzheimer's Disease

Grant number: 19/17532-1
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2020
Effective date (End): March 31, 2024
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Adelino Sanchez Ramos da Silva
Grantee:Gustavo Paroschi Morais
Host Institution: Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The number of people with Dementia is increasing substantially around the world, having a global cost similar to GDP of countries like Netherlands. Brazil occupies the ninth place in this ranking. Alzheimer Disease (AD) is the most prevalent among the neurodegenerative diseases (Dementias), having the formation of ²-amiloide plaques in the brain tissue as a characteristic. One of the factors involved in the ²-amiloide malformation and aggregation is the impairment in the autophagic-lysosomal pathway, decreasing ²-amiloide removal, allowing its aggregation, leading to neurodegeneration. Since its discovery, TFEB has demonstrated a fundamental role in the autophagic-lysosomal pathway. TFEB is the major autophagic coordinator, positively regulating lysosomal biogenesis and autolysosome formation, having the capability to ameliorate the pathological condition in neurodegenerative disease. Physical exercise is an effective approach to prevent neurodegeneration, however, the mechanisms of protection need better elucidation. Physical exercise was capable to improve neural autophagy and decrease neurodegeneration through TFEB, and in skeletal muscle through Calcineurin-TFEB pathway activation, induce autophagy. Furthermore, physical exercise was capable to induce mitochondrial biogenesis, and improve its function in skeletal muscle in a TFEB dependent manner. It is known that mitochondrial disfunctions and neurodegenerative disease have a close correlation, and mitochondrial autophagy has an important role in this condition. Therefore, the main objective of the present study is to verify if TFEB, through the autophagic-lysosomal and mitochondrial biogenesis pathways, along with Calcineurin, would be exerting its neuroprotector effect induced by the physical exercise. Mice will be divided into 4 groups: control (CT; sedentary), trained (TR; submitted to exercise protocol), sedentary AD (SAD; APP/PS1 sedentary), trained AD (TAD; APP/PS1 submitted to exercise protocol). The methods include: immunoblotting, Real-time PCR, immunofluorenscense and brain imaging. Level of significance of p<0.05 will be adopted. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: