Effect of physical exercise on UPRmt, mitochondrial function and beta-amyloid accumulation in the hippocampus of APOE mice - /-

• Grant number: 20/03142-4
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): November 01, 2020
• Effective date (End): November 30, 2022
• Field of knowledge: Biological Sciences - Physiology - Physiology of Effort
• Principal Investigator: Eduardo Rochete Ropelle
• Grantee: Rafael dos Santos Brícola
• Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
• Associated scholarship(s): 22/02041-5 - Effects of Physical Training on AB accumulation, cognitive responses and anti-inflammatory markers in a mouse model of Alzheimer Disease, BE.EP.MS

Abstract

The Alzheimer's disease is a progressive neurodegenerative disease that results in the cognitive impairment of the patients. The etiology of the disease is multifactorial, mainly for some genetic markers such as App, Psen1 / 2 and Apoe, smoking, dyslipidemia, the inflammatory process and others. In this context, mitochondrial dysfunction has been shown as an important contributing factor to the accumulation of beta-amyloid and formation of senile plaques in the hippocampus. A recent study demonstrated that the stimulation of a cellular mechanism known as Unfolded Protein Response (UPRmt), is able to improve the proteostasis and mitochondrial function in the hippocampus, reducing the accumulation of beta-amyloid and senile plaques formation. Interestingly, physical exercise is known to promote positive mitochondrial adaptations, in addition, it is understood to be effective in the prevention and treatment of AD. However, the effect of physical exercise on UPRmt and mitochondrial metabolism in the AD development is unknown. Therefore, the objective of this project is to evaluate the effects of aerobic training on UPRmt markers, mitochondrial function and beta-amyloid accumulation in the hippocampus of hypercholesterolemic mice APOE -/- (a preclinical model of Alzheimer disease). This project may contribute to understand the protective effects of physical exercise on the development of Alzheimer's disease. (AU)