Inhibition of ascitic ehrlich tumor cell growth by intraperitoneal injection of Pfaffia paniculata (Brazilian ginseng) butanolic residue

Autor(es)

Vieira, Juliana ^[1] ; Matsuzaki, Patricia ^[1] ; Nagamine, Marcia Kazumi ^[1] ; Haraguchi, Mitsue ^[2] ; Akisue, Gokithi ^[3] ; Gorniak, Silvana Lima ^[4] ; Zaidan Dagli, Maria Lucia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Patol, Lab Oncol Expt & Comparada, BR-05508900 Sao Paulo - Brazil

^[2] Inst Biol Sao Paulo, Div Biol Anim, Secao Farmacol, BR-04014002 Sao Paulo - Brazil

^[3] Fac Pindamonhangaba, Pindamonhangaba, SP - Brazil

^[4] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Patol, Ctr Pesquisas Toxicol, BR-13635900 Pirassununga, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Archives of Biology and Technology; v. 53, n. 3, p. 609-613, MAY-JUN 2010.
• Citações Web of Science: 3

Resumo

This study aimed to investigate the effects of the administration of butanolic residue (BR) of Pfaffia paniculata by intraperitoneal route to Ehrlich ascitis tumor bearing mice. Initially, a toxicity study of P. paniculata BR was performed in which doses of 12.5; 25 and 50mg/Kg were administered by intraperitoneal injection for seven days to Swiss mice. The treatment did not show toxicity. Then, Swiss male mice received, by intraperitoneal injection, once a day, 12.5; 25 or 50mg/Kg of P. paniculata BR for seven days. This protocol started in the same day of tumor inoculation with 5X10(6) cells i.p. The treatment with butanolic residue of P.paniculata i.p caused a significant increase in the ascitic volume; however, a significant decrease in tumor cells number per ml (p<0.05) was observed in P. paniculata treated mice that was followed by a numerical (although non-significant) decrease in the total numbers of tumor cells in the collected ascitic fluid. These results indicated a tumor cell inhibitory effect by P. paniculata butanolic residue in this experimental system, and indicate that topical application of this residue can be useful to control the cancer growth. (AU)

• Processo FAPESP: 05/50220-0 - Avaliacao dos efeitos do tratamento intraperitoneal com residuo butanolico de pfaffia paniculata, sobre o crescimento do tumor de ehrlich em sua forma ascitica.
• Beneficiário: Juliana Vieira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica