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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Inhibition of ascitic ehrlich tumor cell growth by intraperitoneal injection of Pfaffia paniculata (Brazilian ginseng) butanolic residue

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Author(s):
Vieira, Juliana [1] ; Matsuzaki, Patricia [1] ; Nagamine, Marcia Kazumi [1] ; Haraguchi, Mitsue [2] ; Akisue, Gokithi [3] ; Gorniak, Silvana Lima [4] ; Zaidan Dagli, Maria Lucia [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Patol, Lab Oncol Expt & Comparada, BR-05508900 Sao Paulo - Brazil
[2] Inst Biol Sao Paulo, Div Biol Anim, Secao Farmacol, BR-04014002 Sao Paulo - Brazil
[3] Fac Pindamonhangaba, Pindamonhangaba, SP - Brazil
[4] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Patol, Ctr Pesquisas Toxicol, BR-13635900 Pirassununga, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Brazilian Archives of Biology and Technology; v. 53, n. 3, p. 609-613, MAY-JUN 2010.
Web of Science Citations: 3
Abstract

This study aimed to investigate the effects of the administration of butanolic residue (BR) of Pfaffia paniculata by intraperitoneal route to Ehrlich ascitis tumor bearing mice. Initially, a toxicity study of P. paniculata BR was performed in which doses of 12.5; 25 and 50mg/Kg were administered by intraperitoneal injection for seven days to Swiss mice. The treatment did not show toxicity. Then, Swiss male mice received, by intraperitoneal injection, once a day, 12.5; 25 or 50mg/Kg of P. paniculata BR for seven days. This protocol started in the same day of tumor inoculation with 5X10(6) cells i.p. The treatment with butanolic residue of P.paniculata i.p caused a significant increase in the ascitic volume; however, a significant decrease in tumor cells number per ml (p<0.05) was observed in P. paniculata treated mice that was followed by a numerical (although non-significant) decrease in the total numbers of tumor cells in the collected ascitic fluid. These results indicated a tumor cell inhibitory effect by P. paniculata butanolic residue in this experimental system, and indicate that topical application of this residue can be useful to control the cancer growth. (AU)