| Texto completo | |
| Autor(es): |
Rocha, Michelle P.
[1]
;
Maranhao, Raul C.
[2, 3]
;
Seydell, Talita M.
[3]
;
Barcellos, Cristiano R. G.
[1]
;
Baracat, Edmundo C.
[4]
;
Hayashida, Sylvia A. Y.
[4]
;
Bydlowski, Sergio P.
[5]
;
Marcondes, Jose A. M.
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Endocrinol Sect, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Pharmaceut Sci, Sao Paulo - Brazil
[3] Univ Sao Paulo, Lipid Metab Lab, Heart Inst InCor, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Gynecol & Obstet, Sao Paulo - Brazil
[5] Univ Sao Paulo, Med Sch Hosp, Dept Hematol & Hemotherapy, Sao Paulo - Brazil
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Fertility and Sterility; v. 93, n. 6, p. 1948-1956, APR 2010. |
| Citações Web of Science: | 12 |
| Resumo | |
Objective: To clarify whether the metabolism of triglyceride-rich lipoproteins and lipid transfer to high-density lipoprotein (HDL) are altered in patients with polycystic ovary syndrome (PCOS). Design: Case control study. Setting: Endocrinology clinics. Patient(s): Eight normal-weight (NW) and 15 obese (013) patients with PCOS were compared with 10 NW and 10 Ob women without PCOS paired for age and body mass index. Intervention(s): Determination of triglyceride-rich lipoprotein metabolism and lipid transfer to HDL. Main Outcome Measure(s): Participants were injected triglyceride-rich emulsions labeled with (14)C-cholesteryl esters and (3)H-triglycerides and the fractional clearance rate (FCR, in min(-1)) of labels was determined. Lipid transfer from artificial nanoemulsions to HDL was performed by incubating radioactively labeled lipid nanoemulsions with plasma during 1 hour, followed by radioactive counting of HDL-containing supernatant after chemical precipitation. Result(s): Lipolysis estimated by triglyceride FCR was equal in PCOS groups (NW = 0.043 +/- 0.032, Ob = 0.033 +/- 0.009) and respective controls (NW = 0.039 +/- 0.015, Ob = 0.044 +/- 0.019). However, the remnant removal as estimated by cholesteryl ester FCR was reduced in both PCOS groups (NW = 0.005 +/- 0.006, Ob = 0.005 +/- 0.005) compared with controls (NW = 0.016 +/- 0.006, Ob = 0.011 +/- 0.072). Lipid transfer rates were not different among groups, but triglyceride transfer rates were positively correlated with homeostasis model assessment estimate of insulin resistance in PCOS. Conclusion(s): PCOS patients showed decreased removal of atherogenic remnants even when fasting glucose was <100 mg/dL. This reinforces the usefulness of the measures taken to prevent cardiovascular events in PCOS patients. (Fertil Steril (R) 2010;93:1948-56. (C)2010 by American Society for Reproductive Medicine.) (AU) | |
| Processo FAPESP: | 05/04094-3 - Avaliação do metabolismo de quilomícrons artificiais em pacientes portadoras da síndrome dos ovários policísticos |
| Beneficiário: | José Antonio Miguel Marcondes |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |