Exercise training changes IL-10/TNF-alpha ratio in the skeletal muscle of post-MI rats

Autor(es)

Batista, Jr., M. L. ^{[1, 2]} ; Rosa, J. C. ^[3] ; Lopes, R. D. ^{[4, 5]} ; Lira, F. S. ^[1] ; Martins, Jr., E. ^{[1, 2]} ; Yamashita, A. S. ^[1] ; Brum, P. C. ^[6] ; Lancha, Jr., A. H. ^[6] ; Lopes, A. C. ^[4] ; Seelaender, M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Cell & Dev Biol, Inst Biomed Sci 1, BR-05508900 Sao Paulo - Brazil

^[2] Univ Mogi das Cruzes, Sch Phys Educ, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Physiol, Div Nutr Physiol, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Dept Internal Med, Sao Paulo - Brazil

^[5] Duke Clin Res Inst, Durham, NC - USA

^[6] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CYTOKINE; v. 49, n. 1, p. 102-108, JAN 2010.
• Citações Web of Science: 63

Resumo

Heart failure (HF) is associated with changes in the skeletal muscle (SM) which might be a consequence of the unbalanced local expression of pro- (TNF-alpha) and anti- (IL-10) inflammatory cytokines, leading to inflammation-induced myopathy, and SM wasting. This local effect of HF on SM may, on the other hand, contribute to systemic inflammation, as this tissue actively secretes cytokines. Since increasing evidence points out to an anti-inflammatory effect of exercise training, the goal of the present study was to investigate its effect in rats with HF after post-myocardial infarction (MI), with special regard to the expression of TNF-alpha and IL-10 in the soleus and extensor digitorum longus (EDL), muscles with different fiber composition. Wistar rats underwent left thoracotomy with ligation of the left coronary artery, and were randomly assigned to either a sedentary (Sham-operated and MI sedentary) or trained (Sham-operated and MI trained) group. Animals in the trained groups ran on a treadmill (0% grade at 13-20 m/min) for 60 min/day, 5 days/week, for 8-10 weeks. The training protocol was able to reverse the changes induced by MI, decreasing TNF-alpha protein (26%, P < 0.05) and mRNA (58%, P < 0.05) levels in the soleus, when compared with the sedentary MI group. Training also increased soleus IL-10 expression (2.6-fold, P < 0.001) in post-MI HF rats. As a consequence, the IL-10/TNF-alpha ratio was increased. This ``anti-inflammatory effect{''} was more pronounced in the soleus than in the EDL, suggesting a fiber composition dependent response. (C) 2009 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 05/01445-0 - Papel dos PPARs na caquexia associada ao câncer
• Beneficiário: Marilia Cerqueira Leite Seelaender
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/52782-1 - Bases moleculares da caquexia associada ao câncer: relação do tecido adiposo branco e macrófagos infiltrados
• Beneficiário: Miguel Luiz Batista Junior
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado