Low-Fluoride Acidic Dentifrice: A Randomized Clinical Trial in a Fluoridated Area

Autor(es)

Vilhena, F. V. ^[1] ; Olympio, K. P. K. ^[1] ; Lauris, J. R. P. ^[2] ; Delbem, A. C. B. ^[3] ; Buzalaf, M. A. R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Biol Sci, Bauru Sch Dent, BR-17012901 Bauru, SP - Brazil

^[2] Univ Sao Paulo, Dept Orthodont Pediat Dent & Collect Hlth, Bauru Sch Dent, BR-17012901 Bauru, SP - Brazil

^[3] Sao Paulo State Univ, Aracatuba Sch Dent, Dept Pediat Dent, Aracatuba - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Caries Research; v. 44, n. 5, p. 478-484, 2010.
• Citações Web of Science: 22

Resumo

Background: Low-fluoride dentifrices have been suggested as alternatives to reduce dental fluorosis risk, but there is no consensus regarding their clinical effectiveness, which has been suggested to be increased when their pH is acidic. Aims: This single-blind randomized clinical trial evaluated the caries increment during the use of a low-fluoride acidic liquid dentifrice. Methods: Four-year-old schoolchildren (n = 1,402) living in a fluoridated area (0.6-0.8 ppm F) were randomly allocated to 4 groups differing according to the type of dentifrice used over a 20-month period. Group 1 (n = 345): liquid dentifrice, 1,100 ppm F, pH 4.5. Group 2 (n = 343): liquid dentifrice, 1,100 ppm F, pH 7.0. Group 3 (n = 354): liquid dentifrice, 550 ppm F, pH 4.5. Group 4 (n = 360): toothpaste, 1,100 ppm F, pH 7.0. At baseline and after 20 months, clinical examinations were conducted (dmfs index) and caries increment was calculated. Data were analysed by GLM procedure using classrooms (cluster) as unit of analysis (p < 0.05). Results: The mean +/- SD (95% CI) net increments found were as follows. Group 1: 2.06 +/- 2.38 (1.8-2.3); group 2: 2.08 +/- 2.87 (1.7-2.4); group 3: 2.05 +/- 2.79 (1.7-2.4), and group 4: 2.08 +/- 2.34 (1.8-2.4). No significant differences were detected among the groups. Conclusion: In a population with high caries risk living in a fluoridated area, as the selected sample, and according to the present protocol, the low-fluoride acidic liquid dentifrice seems to lead to similar caries progression rates as conventional 1,100 ppm F toothpaste. Copyright (C) 2010 S. Karger AG, Basel (AU)

• Processo FAPESP: 05/03975-6 - Estudo clínico do efeito de uma nova formulação de dentifrício líquido com pH reduzido e baixa concentração de flúor na prevenção do aparecimento de novas lesões cariosas
• Beneficiário: Marília Afonso Rabelo Buzalaf
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/04090-8 - Estudo clínico do efeito de uma nova formulação de dentifrício líquido com pH reduzido e baixa concentração de flúor na prevenção do aparecimento de novas lesões cariosas
• Beneficiário: Fabiano Vieira Vilhena
• Modalidade de apoio: Bolsas no Brasil - Doutorado