Polymorphisms of xenobiotic metabolizing enzymes and DNA repair genes and outcome in childhood acute lymphoblastic leukemia

Autor(es)

Silveira, Vanessa da Silva ^[1] ; Canalle, Renata ^{[1, 2]} ; Scrideli, Carlos Alberto ^[3] ; de Paula Queiroz, Rosane Gomes ^[3] ; Bettiol, Heloisa ^[3] ; Valera, Elvis Terci ^[3] ; Tone, Luiz Gonzaga ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Genet, Fac Med Ribeirao Preto, BR-14048900 Ribeirao Preto, SP - Brazil

^[2] Univ Fed Piaui, Colegiado Biomed, Parnaiba, Piaui - Brazil

^[3] Univ Sao Paulo, Dept Pediat, Fac Med Ribeirao Preto, BR-14048900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Leukemia Research; v. 33, n. 7, p. 898-901, JUL 2009.
• Citações Web of Science: 24

Resumo

The interindividual variation in the activity of xenobiotic metabolizing enzymes and DNA repair genes could modify an individual's risk of recurrent malignancy and response to therapy. We investigated whether ALL outcome was related to polymorphisms in genes CYP2D6. MPO, EPHX1, NQO1, TS, XPD and XRCC1 in 95 consecutive ALL children by PCR or PCR-FRLP techniques. Polymorphisms in genes NQO1 and TS were associated with a significantly slow response to induction chemotherapy and NQO1 was also associated with a lower five-year event-free survival. This study suggests that polymorphisms of NQO1 and TS could be important for patient response to induction therapy and for treatment outcome. (C) 2009 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 03/02527-4 - Polimorfismos genéticos, suscetibilidade e resposta ao tratamento em crianças portadoras de leucemia linfoblástica aguda
• Beneficiário: Luiz Gonzaga Tone
• Modalidade de apoio: Auxílio à Pesquisa - Regular