Physical Training Leads to Remodeling of Diaphragm Muscle in Asthma Model

Autor(es)

Durigan, J. L. Q. ^[1] ; Peviani, S. M. ^[1] ; Russo, T. L. ^[1] ; Duarte, A. C. ^[2] ; Vieira, R. P. ^[2] ; Martins, M. A. ^[3] ; Carvalho, C. R. F. ^[2] ; Salvini, T. F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Phys Therapy, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Sao Paulo, Dept Phys Therapy, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. 30, n. 6, p. 430-434, JUN 2009.
• Citações Web of Science: 5

Resumo

Matrix metalloproteinases (MMPs) are crucial to the development and maintenance of healthy tissue and are mainly involved in extracellular matrix (ECM) remodeling of skeletal muscle. This study evaluated the effects of chronic allergic airway inflammation (CAAI), induced by ovalbumin, and aerobic training in the MMPs activity in mouse diaphragm muscle. Thirty mice were divided into 6 groups: 1) control; 2) ovalbumin; 3) treadmill trained at 50% of maximum speed; 4) ovalbumin and trained at 50%; 5) trained at 75%; 6) ovalbumin and trained at 75%. CAAI did not after MMPs activities in diaphragm muscle. Nevertheless, both treadmill aerobic trainings, associated with CAAI increased the MMP-2 and -1 activities. Furthermore, MMP-9 was not detected in any group. Together, these findings suggest an ECM remodeling in diaphragm muscle of asthmatic mice submitted to physical training. This result may be useful for a better understanding of functional significance of changes in the MMPs activity in response to physical training in asthma. (AU)

• Processo FAPESP: 05/54747-3 - O efeito da eletroestimulacao na expressao genica, nos parametros eletricos e na morfologia do musculo esqueletico desnervado do rato.
• Beneficiário: Tania de Fatima Salvini
• Modalidade de apoio: Auxílio à Pesquisa - Regular