Association between apolipoprotein E genotype, serum lipids, and colorectal cancer in Brazilian individuals

Autor(es)

Souza, D. R. S. ^[1] ; Nakazone, M. A. ^[1] ; Pinhel, M. A. S. ^[1] ; Alvares, R. M. ^[1] ; Monaco, A. C. ^[1] ; Pinheiro, A. ^[1] ; Barros, C. F. D. C. ^[1] ; Cury, P. M. ^[2] ; Cunrath, G. S. ^[3] ; Netinho, J. G. ^[3]

Afiliação do(s) autor(es)

^[1] Fac Med Sao Jose Rio Preto, Dept Biol Mol, BR-15090000 Sao Jose Do Rio Preto - Brazil

^[2] Fac Med Sao Jose Rio Preto, Dept Patol & Med Legal, BR-15090000 Sao Jose Do Rio Preto - Brazil

^[3] Fac Med Sao Jose Rio Preto, Dept Cirurgia, BR-15090000 Sao Jose Do Rio Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 42, n. 5, p. 397-403, MAY 2009.
• Citações Web of Science: 8

Resumo

We evaluated genetic variants of apolipoprotein E (APOE HhaI) and their association with serum lipids in colorectal cancer (CRC), together with eating habits and personal history. Eight-seven adults with CRC and 73 controls were studied. APOE*2 (rs7412) and APOE*4 (rs429358) were identified by polymerase chain reaction-restriction fragment length polymorphism. APOE gene polymorphisms were similar in both groups, but the ε4/ε4 genotype (6%) was present only in controls. The patients had reduced levels (mean ± SD) of total cholesterol and low-density lipoprotein cholesterol fraction (180.4 ± 49.5 and 116.1 ± 43.1 mg/dL, respectively) compared to controls (204.2 ± 55.6, P = 0.135 and 134.7 ± 50.8 mg/dL; P = 0.330, respectively) indicating that they were not statistically significant after the Bonferroni correction. The APOE*4 allele was associated with lower levels of total cholesterol, low- and high-density lipoprotein cholesterol fraction and increased levels of very low-density lipoprotein cholesterol fraction and triglycerides only among patients (P = 0.014). There was a positive correlation between the altered lipid profile and increased body mass indexes in both groups (P < 0.010). Moreover, a higher rate of hypertension and overweight was observed in controls (P < 0.002). In conclusion, the presence of the ε4/ε4 genotype only in controls may be due to a protective effect against CRC. Lower lipid profile values among patients, even those on lipid-rich diets associated with the APOE*4 allele, suggest alterations in the lipid synthesis and metabolism pathways in CRC. (AU)

• Processo FAPESP: 03/12634-2 - Polimorfismo da apolipoproteina e, perfil lipidico e fatores de risco em pacientes com tumor colo-retal esporadico.
• Beneficiário: Renata de Moura Alvares
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 03/12633-6 - Polimorfismo de apolipoproteina e, perfil lipidico e fatores de risco em pacientes com tumor colo-retal esporadico.
• Beneficiário: Angela Christiane Monaco
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica