A longitudinal study on the transmission dynamics of human Leishmania (Leishmania) infantum chagasi infection in Amazonian Brazil, with special reference to its prevalence and incidence

Autor(es)

Silveira, Fernando T. ^{[1, 2]} ; Lainson, Ralph ^[2] ; Pereira, Elza A. ^[3] ; de Souza, Adelson A. A. ^[2] ; Campos, Marliane B. ^[2] ; Chagas, Eugenia J. ^[4] ; Gomes, Claudia M. C. ^[5] ; Laurenti, Marcia D. ^[5] ; Corbett, Carlos E. P. ^[5]

Afiliação do(s) autor(es)

^[1] Fed Univ Para, Inst Trop Med, BR-66059 Belem, Para - Brazil

^[2] Evandro Chagas Inst, Surveillance Secretary Hlth, Minist Hlth, Dept Parasitol, BR-66090000 Belem, Para - Brazil

^[3] Execut Secretary Publ Hlth, Control Dept Endem Dis, Belem, Para - Brazil

^[4] Hlth Secretary Barcarena Municipal, Dept Publ Hlth, Barcarena, Para - Brazil

^[5] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Parasitology Research; v. 104, n. 3, p. 559-567, FEB 2009.
• Citações Web of Science: 15

Resumo

This was a longitudinal study carried out during a period over 2 years with a cohort of 946 individuals of both sexes, aged 1 year and older, from an endemic area of American visceral leishmaniasis (AVL) in Para State, Brazil. The object was to analyze the transmission dynamics of human Leishmania (Leishmania) infantum chagasi infection based principally on the prevalence and incidence. For diagnosis of the infection, the indirect fluorescent antibody test (IFAT) and leishmanin skin test (LST) were performed with amastigote and promastigote antigens of the parasite, respectively. The prevalence by LST (11.2%) was higher (p < 0.0001) than that (3.4%) by IFAT, and the combined prevalence by both tests was 12.6%. The incidences by LST were also higher (p < 0.05) than those by IFAT at 6 (4.7% A- 0.6%), 12 (4.7% A- 2.7%), and 24 months (2.9% A- 0.3%). Moreover, there were no differences (p > 0.05) between the combined incidences by both tests on the same point surveys, 5.2%, 6.3%, and 3.6%. During the study, 12 infected persons showed high IFAT IgG titers with no LST reactions: five children and two adults developed AVL (2,560-10,120), and two children and three adults developed subclinical oligosymptomatic infection (1,280-2,560). The combined tests diagnosed a total of 231 cases of infection leading to an accumulated prevalence of 24.4%. (AU)

• Processo FAPESP: 06/56319-1 - Leishmanioses no Brasil: aspectos clínicos e imunopatogenéticos da doença humana e experimental
• Beneficiário: Carlos Eduardo Pereira Corbett
• Modalidade de apoio: Auxílio à Pesquisa - Temático